Synergistic effect of ibuprofen with itraconazole and fluconazole against Cryptococcus neoformans
Braz. J. Pharm. Sci. (Online)
;
56: e18599, 2020. tab
Artigo
em Inglês
| LILACS
| ID: biblio-1132042
ABSTRACT
The present study investigated the association of the non-steroidal anti-inflammatory drug ibuprofen with itraconazole, fluconazole and amphotericin B against Cryptococcus neoformans isolates. The minimal inhibitory concentration (MIC) was found according to M27-A3 protocol and in vitro interactions were evaluated using checkerboard microdilution method. Synergism was demonstrated between azoles and ibuprofen for most isolates. However, no synergistic effects were seen when amphotericin B was combined with ibuprofen. Therefore, our results suggest that ibuprofen presents clinical potential when combined with azole drugs in the treatment of cryptococcosis.
Texto completo:
DisponíveL
Índice:
LILACS (Américas)
Assunto principal:
Fluconazol
/
Ibuprofeno
/
Itraconazol
/
Cryptococcus neoformans
Tipo de estudo:
Guia de Prática Clínica
Idioma:
Inglês
Revista:
Braz. J. Pharm. Sci. (Online)
Assunto da revista:
Farmacologia
/
Teraputica
/
Toxicologia
Ano de publicação:
2020
Tipo de documento:
Artigo
País de afiliação:
Brasil
Instituição/País de afiliação:
Universidade Federal do Rio Grande do Sul/BR
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