Melatonin decreases cocaine-induced locomotor activity in pinealectomized rats
Braz. J. Psychiatry (São Paulo, 1999, Impr.)
;
42(3): 295-308, May-June 2020. graf
Artigo
em Inglês
| LILACS
| ID: biblio-1132066
ABSTRACT
Objective:
Several studies have shown that the time of day regulates the reinforcing effects of cocaine. Additionally, melatonin and its MT1 and MT2 receptors have been found to participate in modulation of the reinforcing effects of such addictive drugs as cocaine. Loss of the diurnal variation in cocaine-induced locomotor sensitization and cocaine-induced place preference has been identified in pinealectomized mice. In addition, several studies in rodents have shown that administration of melatonin decreased the reinforcing effects of cocaine. The objective of this study was to evaluate the effect of melatonin on cocaine-induced locomotor activity in pinealectomized rats at different times of day (zeitgeber time [ZT]4, ZT10, ZT16, and ZT22).Methods:
Naïve, pinealectomized Wistar rats received cocaine at different times of day. Melatonin was administered 30 min before cocaine; luzindole was administered 15 min prior to melatonin and 45 min before cocaine. After administration of each treatment, locomotor activity for each animal was recorded for a total of 30 min. Pinealectomy was confirmed at the end of the experiment through melatonin quantitation by ELISA.Results:
Cocaine-induced locomotor activity varied according to the time of day. Continuous lighting and pinealectomy increased cocaine-induced locomotor activity. Melatonin administration decreased cocaine-induced locomotor activity in naïve and pinealectomized rats at different times of day. Luzindole blocked the melatonin-induced reduction in cocaine-induced locomotor activity in pinealectomized rats.Conclusion:
Given its ability to mitigate various reinforcing effects of cocaine, melatonin could be a useful therapy for cocaine abuse.
Texto completo:
DisponíveL
Índice:
LILACS (Américas)
Assunto principal:
Depressores do Sistema Nervoso Central
/
Transtornos Relacionados ao Uso de Cocaína
/
Pinealectomia
/
Locomoção
/
Melatonina
Tipo de estudo:
Ensaio Clínico Controlado
/
Estudos de avaliação
/
Estudo prognóstico
Limite:
Animais
/
Humanos
/
Masculino
Idioma:
Inglês
Revista:
Braz. J. Psychiatry (São Paulo, 1999, Impr.)
Assunto da revista:
Psiquiatria
Ano de publicação:
2020
Tipo de documento:
Artigo
País de afiliação:
México
Instituição/País de afiliação:
Instituto Nacional de Psiquiatría/MX
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