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Correlation between amyloid deposits affecting renal compartments and glomerular filtration rate during renal biopsy in a renal amyloidosis case series
Fonseca, E O; Caldas, M L R; Soares Filho, P J; Almeida, J R.
  • Fonseca, E O; Universidade Federal Fluminense. Hospital Universitário Antônio Pedro. Niterói. BR
  • Caldas, M L R; Universidade Federal Fluminense. Hospital Universitário Antônio Pedro. Niterói. BR
  • Soares Filho, P J; Universidade Federal Fluminense. Hospital Universitário Antônio Pedro. Niterói. BR
  • Almeida, J R; Universidade Federal Fluminense. Hospital Universitário Antônio Pedro. Niterói. BR
Braz. j. med. biol. res ; 53(6): e8625, 2020. tab, graf
Artigo em Inglês | LILACS, ColecionaSUS | ID: biblio-1132515
ABSTRACT
Amyloidosis comprises a group of disorders that accumulate modified autologous proteins in organs, mainly the kidneys. Few studies have addressed the amyloid compartmental distribution and associated clinical outcomes. The aim of this study was to present a case series of renal amyloidosis correlating histopathological data with glomerular filtration rate (GFR) during kidney biopsy. We studied 53 cases reviewed by nephropathologists from 2000 to 2018 in a single kidney biopsy center in Brazil. GFR was estimated using the CKD-EPI formula. Cases were divided into Group A ≥60 and Group B <60 mL·min−1·(1.73 m2)−1 using the estimated GFR during kidney biopsy. Semiquantitative histopathological study was performed, including extension and distribution of amyloid deposits by compartments (glomeruli, tubulointerstitial tissue, and vessels). Statistical analyses were made to understand associations with lower GFR. No difference was seen for age, gender, proteinuria, hematuria, subtype of amyloid protein, arteriosclerosis, interstitial fibrosis/infiltrate, or glomerular and interstitial amyloid deposits. After a previous P value <0.1 in the descriptive analysis, the following variables were selected globally sclerotic glomeruli, high blood pressure, and the extension of vascular amyloid deposition. A binary logistic regression model with GFR as the dependent variable showed history of hypertension and vascular amyloid to be robust and independent predictors of Group B <60 mL·min−1·(1.73 m2)−1. Beyond the histopathologic diagnosis of amyloidosis, a semiquantitative approach on renal biopsy could provide new insights. Vascular amyloid is an independent predictor of renal dysfunction in cases of renal amyloidosis.
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Texto completo: DisponíveL Índice: LILACS (Américas) Assunto principal: Taxa de Filtração Glomerular / Amiloide / Amiloidose / Rim / Nefropatias Tipo de estudo: Estudo observacional / Estudo prognóstico / Fatores de risco Limite: Adulto / Idoso / Feminino / Humanos / Masculino Idioma: Inglês Revista: Braz. j. med. biol. res Ano de publicação: 2020 Tipo de documento: Artigo Instituição/País de afiliação: Universidade Federal Fluminense/BR

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Texto completo: DisponíveL Índice: LILACS (Américas) Assunto principal: Taxa de Filtração Glomerular / Amiloide / Amiloidose / Rim / Nefropatias Tipo de estudo: Estudo observacional / Estudo prognóstico / Fatores de risco Limite: Adulto / Idoso / Feminino / Humanos / Masculino Idioma: Inglês Revista: Braz. j. med. biol. res Ano de publicação: 2020 Tipo de documento: Artigo Instituição/País de afiliação: Universidade Federal Fluminense/BR