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Animal models of human atherosclerosis: current progress
Poznyak, A V; Silaeva, Y Y; Orekhov, A N; Deykin, A V.
  • Poznyak, A V; Institute for Atherosclerosis Research, Skolkovo Innovative Center. Moscow. RU
  • Silaeva, Y Y; Russian Academy of Sciences. Institute of Gene Biology. Core Facility Centre. Moscow. RU
  • Orekhov, A N; Institute for Atherosclerosis Research, Skolkovo Innovative Center. Moscow. RU
  • Deykin, A V; Russian Academy of Sciences. Institute of Gene Biology. Core Facility Centre. Moscow. RU
Braz. j. med. biol. res ; 53(6): e9557, 2020. tab
Artigo em Inglês | LILACS, ColecionaSUS | ID: biblio-1132517
ABSTRACT
Atherosclerosis retains the leading position among the causes of global morbidity and mortality worldwide, especially in the industrialized countries. Despite the continuing efforts to investigate disease pathogenesis and find the potential points of effective therapeutic intervention, our understanding of atherosclerosis mechanisms remains limited. This is partly due to the multifactorial nature of the disease pathogenesis, when several factors so different as altered lipid metabolism, increased oxidative stress, and chronic inflammation act together leading to the formation and progression of atherosclerotic plaques. Adequate animal models are currently indispensable for studying these processes and searching for novel therapies. Animal models based on rodents, such as mice and rats, and rabbits represent important tools for studying atherosclerosis. Currently, genetically modified animals allow for previously unknown possibilities in modelling the disease and its most relevant aspects. In this review, we describe the recent progress made in creating such models and discuss the most important findings obtained with them to date.
Assuntos


Texto completo: DisponíveL Índice: LILACS (Américas) Assunto principal: Modelos Animais de Doenças / Aterosclerose Tipo de estudo: Estudo prognóstico Limite: Animais / Humanos Idioma: Inglês Revista: Braz. j. med. biol. res Ano de publicação: 2020 Tipo de documento: Artigo Instituição/País de afiliação: Institute for Atherosclerosis Research, Skolkovo Innovative Center/RU / Russian Academy of Sciences/RU

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Texto completo: DisponíveL Índice: LILACS (Américas) Assunto principal: Modelos Animais de Doenças / Aterosclerose Tipo de estudo: Estudo prognóstico Limite: Animais / Humanos Idioma: Inglês Revista: Braz. j. med. biol. res Ano de publicação: 2020 Tipo de documento: Artigo Instituição/País de afiliação: Institute for Atherosclerosis Research, Skolkovo Innovative Center/RU / Russian Academy of Sciences/RU