Non-inferiority clinical trials: importance and applications in health sciences
Braz. oral res. (Online)
;
34(supl.2): e072, 2020. graf
Artigo
em Inglês
| LILACS, BBO
| ID: biblio-1132738
ABSTRACT
Abstract Non-inferiority randomized clinical trials are indicated when it is intended to prove that an experimental group is not inferior to a control group by more than a margin of non-inferiority. However, this type of study differs from traditional randomized clinical trials (superiority studies) because they have particularities that impact on the formulation of hypothesis to be tested, experimental design (non-inferiority margin determination, adapted sample size calculation, sensitivity of the study and data final analysis) and also on the presentation of data when writing the manuscript. Therefore, this article aims to present and discuss the particularities of non-inferiority clinical studies, since these requirements are fundamental to guarantee the validity of the conclusions of this type of study.
Texto completo:
DisponíveL
Índice:
LILACS (Américas)
Assunto principal:
Projetos de Pesquisa
Tipo de estudo:
Ensaio Clínico Controlado
Idioma:
Inglês
Revista:
Braz. oral res. (Online)
Assunto da revista:
Odontologia
Ano de publicação:
2020
Tipo de documento:
Artigo
País de afiliação:
Brasil
Instituição/País de afiliação:
Universidade de São Paulo/BR
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