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Analysis of the clinical effects of the combination of mycophenolate mofetil with either tacrolimus or cyclophosphamide
Zhang, Xuebing; Liu, Pei; Zhang, Zhen.
  • Zhang, Xuebing; Lanling County Peoples Hospital. Department of Nephrology. Linyi. CN
  • Liu, Pei; Lanling County Peoples Hospital. Department of Nephrology. Linyi. CN
  • Zhang, Zhen; Lanling County Peoples Hospital. Department of Nephrology. Linyi. CN
Clinics ; 75: e1820, 2020. tab, graf
Artigo em Inglês | LILACS | ID: biblio-1133440
ABSTRACT

OBJECTIVES:

Here, we aimed to compare the clinical effects of mycophenolate mofetil combined with either tacrolimus or with cyclophosphamide on lupus nephritis (LN) and to analyze their influence on the expression of cystatin C and on transforming growth factor-1 (TGF-β1).

METHODS:

A total of 234 patients were randomly divided into two groups group A, for mycophenolate mofetil combined with tacrolimus (n=117) and group B, for mycophenolate mofetil combined with cyclophosphamide (n=117). The enzyme-linked immunosorbent assay was adopted to detect the expression levels of serum TGF-β1 and cystatin C before and after treatment.

RESULTS:

The total effectiveness rate in group A was much higher than that in group B. The times of effectiveness and effect validity in group A were much lower than those in group B. The expression levels of serum TGF-β1 and cystatin C decreased slightly after treatment in the two groups, and those of group A were much lower than those of group B.

CONCLUSIONS:

The combination of mycophenolate mofetil and tacrolimus showed better clinical efficacy on LN and was safer than that of mycophenolate mofetil and cyclophosphamide. Moreover, the drug combination of mycophenolate mofetil and tacrolimus greatly reduced the expression levels of serum TGF-β1 and cystatin C.
Assuntos


Texto completo: DisponíveL Índice: LILACS (Américas) Assunto principal: Nefrite Lúpica / Ácido Micofenólico Tipo de estudo: Ensaio Clínico Controlado Limite: Humanos Idioma: Inglês Revista: Clinics Assunto da revista: Medicina Ano de publicação: 2020 Tipo de documento: Artigo País de afiliação: China Instituição/País de afiliação: Lanling County Peoples Hospital/CN

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Texto completo: DisponíveL Índice: LILACS (Américas) Assunto principal: Nefrite Lúpica / Ácido Micofenólico Tipo de estudo: Ensaio Clínico Controlado Limite: Humanos Idioma: Inglês Revista: Clinics Assunto da revista: Medicina Ano de publicação: 2020 Tipo de documento: Artigo País de afiliação: China Instituição/País de afiliação: Lanling County Peoples Hospital/CN