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Real-world molecular testing and treatment patterns in brazilian patients with newly diagnosed locally advanced or metastatic NSCLC
Cronemberger, Eduardo; Baldotto, Clarissa; Marinho, Felipe; De Marchi, Pedro; Araújo, Luiz Henrique; Franke, Fabio; Salles, Paulo; Calabrich, Aknar; Almeida, Thaís; Custodio, Marcelo Graziano; Maria, André Santa; Pereira, Marcelo Horacio; Castro Jr, Gilberto.
  • Cronemberger, Eduardo; Centro Regional Integrado de Oncologia (CRIO). Fortaleza. BR
  • Baldotto, Clarissa; Instituto DOr de Pesquisa e Ensino. Oncologia. Rio de Janeiro. BR
  • Marinho, Felipe; Hospital de Cancer de Pernambuco. Recife. BR
  • De Marchi, Pedro; Hospital de Cancer de Barretos. Barretos. BR
  • Araújo, Luiz Henrique; Instituto Nacional de Cancer (INCA). Rio de Janeiro. BR
  • Franke, Fabio; Associacao Hospital de Caridade Ijui. Ijui. BR
  • Salles, Paulo; Instituto Mario Penna. Belo Horizonte. BR
  • Calabrich, Aknar; Clinica AMO. Salvador. BR
  • Almeida, Thaís; Instituto de Oncologia do Parana. Curitiba. BR
  • Custodio, Marcelo Graziano; AstraZeneca. Cotia. BR
  • Maria, André Santa; AstraZeneca. Cotia. BR
  • Pereira, Marcelo Horacio; AstraZeneca. Cotia. BR
  • Castro Jr, Gilberto; Instituto do Cancer do Estado de Sao Paulo (ICESP). Sao Paulo. BR
Clinics ; 75: e1777, 2020. tab, graf
Artigo em Inglês | LILACS | ID: biblio-1133470
ABSTRACT
OBJECTIVES: To evaluate the molecular testing and treatment patterns in a retrospective cohort of newly diagnosed treatment-naïve patients with locally advanced or metastatic non-small-cell lung cancer (NSCLC). METHODS: This is an observational retrospective cohort study conducted across 10 cancer centers in Brazil. Treatment-naïve patients with locally advanced or metastatic NSCLC were enrolled from January to December 2014. The following data were collected from the medical records of patients from diagnosis until the last record (death, loss to follow-up, or the end of the maximum follow-up period): demographics; medical history; smoking status; disease characteristics; previous treatments; and molecular testing patterns and results. The overall survival (OS) was also estimated. Results: A total of 391 patients from 8 different Brazilian states were included, with a median age of 64.1 years (23.7-98.7), with most patients being males (60.1%). The smoking status of 74.2% of patients was a 'former' or 'current smoker'. Stage IV NSCLC at diagnosis was observed in 82.4% of patients, with 269 of them (68.8%) presenting adenocarcinoma (ADC). Among the stage IV ADC patients, 54.0% were referred for molecular testing. Among the patients with an available epidermal growth factor receptor (EGFR) mutation status, 31 (24.0%) were EGFR-positive. The first-line treatment was a platinum-based chemotherapy for 98 patients (25.1%), while non-platinum-based regimens were used in 54 patients (13.8%). OS data were available for 370 patients, with a median OS of 10.8 months. Never smokers had a significantly higher median OS versus current or former smokers (14.6 versus 9.1 months; log-rank p=0.003). Among the patients for whom molecular testing data were available, those with EGFR-positive results had a longer median OS (34.6 versus 12.8 months; log-rank p=0.003). Conclusion: Our findings provide relevant information for prescribers and policy decision-makers by highlighting the unmet needs of patients and the importance of molecular testing in newly diagnosed locally advanced or metastatic lung adenocarcinoma. We also highlight the respective EGFR-tyrosine kinase inhibitor treatment when the result is positive and the areas in which further efforts are required to grant access to effective treatment.
Assuntos


Texto completo: DisponíveL Índice: LILACS (Américas) Assunto principal: Carcinoma Pulmonar de Células não Pequenas / Neoplasias Pulmonares Tipo de estudo: Estudo diagnóstico / Estudo observacional / Estudo prognóstico Limite: Humanos / Masculino País/Região como assunto: América do Sul / Brasil Idioma: Inglês Revista: Clinics Assunto da revista: Medicina Ano de publicação: 2020 Tipo de documento: Artigo País de afiliação: Brasil Instituição/País de afiliação: Associacao Hospital de Caridade Ijui/BR / AstraZeneca/BR / Centro Regional Integrado de Oncologia (CRIO)/BR / Clinica AMO/BR / Hospital de Cancer de Barretos/BR / Hospital de Cancer de Pernambuco/BR / Instituto DOr de Pesquisa e Ensino/BR / Instituto Mario Penna/BR / Instituto Nacional de Cancer (INCA)/BR / Instituto de Oncologia do Parana/BR

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Texto completo: DisponíveL Índice: LILACS (Américas) Assunto principal: Carcinoma Pulmonar de Células não Pequenas / Neoplasias Pulmonares Tipo de estudo: Estudo diagnóstico / Estudo observacional / Estudo prognóstico Limite: Humanos / Masculino País/Região como assunto: América do Sul / Brasil Idioma: Inglês Revista: Clinics Assunto da revista: Medicina Ano de publicação: 2020 Tipo de documento: Artigo País de afiliação: Brasil Instituição/País de afiliação: Associacao Hospital de Caridade Ijui/BR / AstraZeneca/BR / Centro Regional Integrado de Oncologia (CRIO)/BR / Clinica AMO/BR / Hospital de Cancer de Barretos/BR / Hospital de Cancer de Pernambuco/BR / Instituto DOr de Pesquisa e Ensino/BR / Instituto Mario Penna/BR / Instituto Nacional de Cancer (INCA)/BR / Instituto de Oncologia do Parana/BR