COVID-19: molecular targets, drug repurposing and new avenues for drug discovery
Mem. Inst. Oswaldo Cruz
;
115: e200254, 2020. tab, graf
Artigo
em Inglês
| LILACS, SES-SP
| ID: biblio-1135246
ABSTRACT
Coronavirus disease 2019 (COVID-19) caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a highly contagious infection that may break the healthcare system of several countries. Here, we aimed at presenting a critical view of ongoing drug repurposing efforts for COVID-19 as well as discussing opportunities for development of new treatments based on current knowledge of the mechanism of infection and potential targets within. Finally, we also discuss patent protection issues, cost effectiveness and scalability of synthetic routes for some of the most studied repurposing candidates since these are key aspects to meet global demand for COVID-19 treatment.
Texto completo:
DisponíveL
Índice:
LILACS (Américas)
Assunto principal:
Pneumonia Viral
/
Infecções por Coronavirus
/
Descoberta de Drogas
/
Reposicionamento de Medicamentos
Limite:
Humanos
Idioma:
Inglês
Revista:
Mem. Inst. Oswaldo Cruz
Ano de publicação:
2020
Tipo de documento:
Artigo
Instituição/País de afiliação:
Fundação Oswaldo Cruz-Fiocruz/BR
/
Universidade Federal do Rio de Janeiro/BR
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