Genomic and phylogenetic characterisation of an imported case of SARS-CoV-2 in Amazonas State, Brazil
Mem. Inst. Oswaldo Cruz
;
115: e200310, 2020. tab, graf
Artigo
em Inglês
| LILACS, SES-SP
| ID: biblio-1135251
ABSTRACT
A new coronavirus [severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)] is currently causing a life-threatening pandemic. In this study, we report the complete genome sequencing and genetic characterisation of a SARS-CoV-2 detected in Manaus, Amazonas, Brazil, and the protocol we designed to generate high-quality SARS-CoV-2 full genome data. The isolate was obtained from an asymptomatic carrier returning from Madrid, Spain. Nucleotide sequence analysis showed a total of nine mutations in comparison with the original human case in Wuhan, China, and support this case as belonging to the recently proposed lineage A.2. Phylogeographic analysis further confirmed the likely European origin of this case. To our knowledge, this is the first SARS-CoV-2 genome obtained from the North Brazilian Region. We believe that the information generated in this study may contribute to the ongoing efforts toward the SARS-CoV-2 emergence.
Texto completo:
DisponíveL
Índice:
LILACS (Américas)
Assunto principal:
Filogenia
/
Pneumonia Viral
/
Infecções por Coronavirus
/
Betacoronavirus
Limite:
Humanos
País/Região como assunto:
América do Sul
/
Brasil
/
Europa
Idioma:
Inglês
Revista:
Mem. Inst. Oswaldo Cruz
Ano de publicação:
2020
Tipo de documento:
Artigo
Instituição/País de afiliação:
Fundação Oswaldo Cruz-Fiocruz/BR
/
Fundação de Vigilância em Saúde do Amazonas/BR
/
Universidade Federal do Espírito Santo/BR
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