Coagulation modifiers targeting SARS-CoV-2 main protease Mpro for COVID-19 treatment: an in silico approach
Mem. Inst. Oswaldo Cruz
;
115: e200179, 2020. graf
Artigo
em Inglês
| LILACS, SES-SP
| ID: biblio-1135266
ABSTRACT
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection depends on viral polyprotein processing, catalysed by the main proteinase (Mpro). The solution of the SARS-CoV-2 Mpro structure allowed the investigation of potential inhibitors. This work aims to provide first evidences of the applicability of commercially approved drugs to treat coronavirus disease-19 (COVID-19). We screened 4,334 compounds to found potential inhibitors of SARS-CoV-2 replication using an in silico approach. Our results evidenced the potential use of coagulation modifiers in COVID-19 treatment due to the structural similarity of SARS-CoV-2 Mpro and human coagulation factors thrombin and Factor Xa. Further in vitro and in vivo analysis are needed to corroborate these results.
Texto completo:
DisponíveL
Índice:
LILACS (Américas)
Assunto principal:
Inibidores de Proteases
/
Proteínas não Estruturais Virais
/
Betacoronavirus
Tipo de estudo:
Estudo prognóstico
Limite:
Humanos
Idioma:
Inglês
Revista:
Mem. Inst. Oswaldo Cruz
Ano de publicação:
2020
Tipo de documento:
Artigo
Instituição/País de afiliação:
Fundação Oswaldo Cruz-Fiocruz/BR
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