CD14 genotype and functional dichotomy of CD14+ and CD14- cells are associated with activated immune response and development of Chagas dilated cardiomyopathy
Mem. Inst. Oswaldo Cruz
;
115: e200110, 2020. tab, graf
Artigo
em Inglês
| LILACS, SES-SP
| ID: biblio-1135276
ABSTRACT
We aimed to investigate the association of CD14 -260C/T (rs2569190) polymorphism and Chagas cardiomyopathy and the functional characteristics of CD14+ and CD14- monocytes upon infection with Trypanosoma cruzi. We observed an association between the T- genotype (absence of allele -260T) related to low CD14 expression and the dilated cardiomyopathy type of Chagas disease. Furthermore, we observed that CD14- monocytes showed a more activated profile upon in vitro infection with T. cruzi than CD14+ monocytes. Our findings suggest that T- genotype is associated with susceptibility to develop Chagas dilated cardiomyopathy, likely linked to the T. cruzi-induced inflammatory profile of CD14- monocytes.
Texto completo:
DisponíveL
Índice:
LILACS (Américas)
Assunto principal:
Cardiomiopatia Dilatada
/
Cardiomiopatia Chagásica
/
Receptores de Lipopolissacarídeos
Tipo de estudo:
Fatores de risco
Limite:
Humanos
Idioma:
Inglês
Revista:
Mem. Inst. Oswaldo Cruz
Ano de publicação:
2020
Tipo de documento:
Artigo
Instituição/País de afiliação:
AC Camargo Cancer Center/BR
/
Pontifícia Universidade Católica de Minas Gerais/BR
/
Universidade Federal de Minas Gerais/BR
/
Universidade Federal de Viçosa/BR
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