Risk factors associated with drug therapy among elderly people with Alzheimers disease: a cross-sectional study
São Paulo med. j
;
138(3): 216-218, May-June 2020. tab, graf
Artigo
em Inglês
| LILACS, SES-SP
| ID: biblio-1139694
ABSTRACT
ABSTRACT BACKGROUND:
Improving knowledge and establishing strategies and policies for better patient safety are worldwide priorities.OBJECTIVE:
To evaluate drug safety among elderly people with Alzheimer's disease (AD). DESIGN ANDSETTING:
Cross-sectional study among elderly people within the National AD Assistance Protocol (PCDTDA/MS) who were living in the municipality of Araraquara, Brazil, in 2017.METHODS:
Through interviews conducted with relatives/caregivers of elderly people with diagnoses of AD, the following variables were evaluated comorbidities, drug therapy used, use of potentially inappropriate medications for the elderly (PIMs), presence of potentially inappropriate interactions (PIIs) and medication regimen complexity index. Factors associated with AD severity were also evaluated. Multivariate and simple logistic regressions were applied.RESULTS:
143 elderly people enrolled in PCDTDA/MS were analyzed. The majority were women (67.1%); assisted only through the public healthcare system (75.5%); polymedicated (57.4%); using at least one PIM (63.6%); presenting at least one PII (63.6%); and under drug therapy of low to medium complexity (92.2%). No semi-annual monitoring of the effectiveness of PCDTDA/MS drugs was identified. The proportion using AD drug therapy at daily doses differing from those recommended by the World Health Organization was 75.6%. However, these doses were not associated with drug risk.CONCLUSION:
The data from this study raise the hypothesis that use of polypharmacy might show a correlation with severity of AD. The drug safety risk may be associated with comorbidities of the metabolic syndrome, anxiety and off-label use of PIMs, such as risperidone and quetiapine, and benzodiazepines (i.e. clonazepam and flunitrazepam).
Texto completo:
DisponíveL
Índice:
LILACS (Américas)
Assunto principal:
Doença de Alzheimer
Tipo de estudo:
Estudo de etiologia
/
Guia de Prática Clínica
/
Estudo observacional
/
Estudo de prevalência
/
Estudo prognóstico
/
Fatores de risco
Limite:
Idoso
/
Feminino
/
Humanos
/
Masculino
País/Região como assunto:
América do Sul
/
Brasil
Idioma:
Inglês
Revista:
São Paulo med. j
Ano de publicação:
2020
Tipo de documento:
Artigo
Instituição/País de afiliação:
Universidade Estadual Paulista/BR
/
Universidade Federal de São Paulo/BR
/
Universidade de Aveiro/PT
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