Association of the polymorphism Exon 1 (A/O) region of the mannose-binding lectin gene and periportal fibrosis regression in schistosomiasis after specific treatment
Rev. Soc. Bras. Med. Trop
;
54: e01452020, 2021. tab, graf
Artigo
em Inglês
| SES-SP, ColecionaSUS, LILACS
| ID: biblio-1143891
ABSTRACT
Abstract INTRODUCTION:
We evaluated the association between genetic polymorphisms in exon 1 (A/O alleles) and promoter regions at positions -550 (H/L variant, rs11003125) and -221 (X/Y variant, rs7096206) MBL2 and periportal fibrosis regression.METHODS:
This was a retrospective cohort study involving 114 Brazilians infected with Schistosoma mansoni, who were subjected to follow-up for three years after specific treatment for schistosomiasis to estimate the probability of periportal fibrosis regression.RESULTS:
A risk association was observed between polymorphism at the exon 1 MBL2 and periportal fibrosis regression.CONCLUSIONS:
This study suggests that the polymorphism of exon 1 MBL2 may potentially be used to predict periportal fibrosis regression in this population.
Texto completo:
DisponíveL
Índice:
LILACS (Américas)
Assunto principal:
Esquistossomose
/
Lectina de Ligação a Manose
Tipo de estudo:
Estudo observacional
/
Estudo prognóstico
/
Fatores de risco
Limite:
Animais
/
Humanos
País/Região como assunto:
América do Sul
/
Brasil
Idioma:
Inglês
Revista:
Rev. Soc. Bras. Med. Trop
Ano de publicação:
2021
Tipo de documento:
Artigo
Instituição/País de afiliação:
Universidade Federal de Pernambuco/BR
/
Universidade de Pernambuco/BR
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