Inhibitory activity of Varronia curassavica and Mikania laevigatafractions against pathogens associated with persistent dental infections
Rev. ciênc. farm. básica apl
;
41: [10], 01/01/2020.
Artigo
em Inglês
| LILACS
| ID: biblio-1147075
ABSTRACT
Herbal medicines have been studied as potential antimicrobial agents, emerging as treatments against oral diseases. The current study evaluated the antimicrobial activity of the crude extract and fractions of Mikania laevigata SchultzBip. ex Baker (ML) and Varronia curassavicaJacq (VC) against oral pathogens associated with persistent dental root infections, under planktonic and biofilm conditions. Minimal inhibitory concentrations and minimal bactericidal/fungicidal concentrations were determined for the ML and VC fractions/extracts against Enterococcus faecalis, Actinomyces israelii, Pseudomonas aeruginosa, and Candida albicans using the microdilution method. The best results were chosen for subsequent biofilm assays. All tested ML and VC extracts/fractions demonstrated inhibitory activity against E. faecalis and A. israelii. The ML ethyl acetate fraction affected the growth of all microorganisms tested. C. albicans and P. aeruginosawere not affected by any VC extract/fractions. The ML ethyl acetate fraction eliminated E. faecalis, A.israelii, and P. aeruginosa biofilms after 24h. A similar result was observed for ML crude hydroethanolic extract and its hexane fraction for A. israelii. The VC hexane fraction was able to eliminate A. israelli biofilms. None of the tested extracts or fractions eliminated C. albicans biofilm. The Mikania laevigata ethyl acetate fraction is an efficient antimicrobial agent against oral pathogens and could be indicated for the treatment of persistent dental infections.
Texto completo:
DisponíveL
Índice:
LILACS (Américas)
Assunto principal:
Análise de Mediação
Tipo de estudo:
Fatores de risco
Idioma:
Inglês
Revista:
Rev. ciênc. farm. básica apl
Assunto da revista:
Farmacologia
Ano de publicação:
2020
Tipo de documento:
Artigo
País de afiliação:
Brasil
Instituição/País de afiliação:
Departamento de Odontologia Preventiva e Restauradora/BR
/
Departamento de Princípios Ativos Naturais e Toxicologia/BR
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