BDNF Val66Met polymorphism and resilience in major depressive disorder: the impact of cognitive psychotherapy
Braz. J. Psychiatry (São Paulo, 1999, Impr.)
;
43(1): 22-28, Jan.-Feb. 2021. tab, graf
Artigo
em Inglês
| LILACS
| ID: biblio-1153276
ABSTRACT
Objective:
Clinical and biological correlates of resilience in major depressive disorder are scarce. We aimed to investigate the effect of the Val66Met polymorphism in the BDNF gene on resilience scores in major depressive disorder patients and evaluate the polymorphism's moderation effect on resilience scores in response to cognitive therapy.Method:
A total of 106 major depressive disorder patients were enrolled in this clinical randomized study. The Resilience Scale and the Hamilton Rating Scale for Depression were applied at baseline, post-treatment, and at six months of follow-up. Blood samples were obtained at baseline for molecular analysis.Results:
The baseline resilience scores were higher in patients with the Met allele (114.6±17.6) than in those with the Val/Val genotype (104.04±21.05; p = 0.037). Cognitive therapy treatment increased resilience scores (p ≤ 0.001) and decreased depressive symptoms (p ≤ 0.001). In the mixed-effect model, the Val/Val genotype represented a decrease in resilience scores (t218 = -1.98; p = 0.048), and the Val66Met polymorphism interacted with sex to predict an increase in total resilience scores during cognitive treatment (t218 = 2.69; p = 0.008).Conclusion:
Our results indicate that cognitive therapy intervention could improve resilience in follow-up, considering that gender and genetic susceptibility are predicted by the Val66Met polymorphism.
Texto completo:
DisponíveL
Índice:
LILACS (Américas)
Assunto principal:
Terapia Cognitivo-Comportamental
/
Transtorno Depressivo Maior
Tipo de estudo:
Ensaio Clínico Controlado
/
Estudo prognóstico
Limite:
Humanos
Idioma:
Inglês
Revista:
Braz. J. Psychiatry (São Paulo, 1999, Impr.)
Assunto da revista:
Psiquiatria
Ano de publicação:
2021
Tipo de documento:
Artigo
País de afiliação:
Brasil
/
Canadá
Instituição/País de afiliação:
McMaster University/CA
/
Universidade Católica de Pelotas (UCPel)/BR
/
Universidade Federal de Pelotas (UFPel)/BR
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