Transcatheter Interatrial Shunts for the Treatment of Heart Failure with Preserved Ejection Fraction
Int. j. cardiovasc. sci. (Impr.)
;
34(1): 81-88, Jan.-Feb. 2021. tab, graf
Artigo
em Inglês
| LILACS
| ID: biblio-1154539
ABSTRACT
Abstract Heart failure with preserved ejection fraction (HFpEF) is a clinical syndrome, which accounts for about 50% of patients with heart failure (HF). The morbidity and mortality associated with HFpEF is similar to HFrEF. Clinical trials to date have failed to show a benefit of medical therapy for HFpEF, which may due to lack of uniform phenotypes and heterogeneous population. In addition, medical therapy proven for HFrEF may not address the pathophysiologic basis for HFpEF. Left atrial remodeling and dysfunction is central to HFpEF and accounts for secondary pulmonary hypertension and pulmonary vascular congestion that frequently occurs with exertion. Interatrial shunts represent a novel treatment modality for HFpEF. These shunts allow for left atrial decongestion and a reduction in pulmonary venous hypertension during exercise leading to improvements in hemodynamics, functional status and quality of life. Trials to date have demonstrated safety and short-term efficacy of these devices for HFpEF. The long-term benefits are currently being evaluated in ongoing trials. If effective, the use of interatrial shunts may be a new therapeutic paradigm for the treatment of HFpEF.
Texto completo:
DisponíveL
Índice:
LILACS (Américas)
Assunto principal:
Insuficiência Cardíaca Diastólica
/
Substituição da Valva Aórtica Transcateter
Tipo de estudo:
Estudo diagnóstico
Idioma:
Inglês
Revista:
Int. j. cardiovasc. sci. (Impr.)
Assunto da revista:
Cardiologia
Ano de publicação:
2021
Tipo de documento:
Artigo
País de afiliação:
Estados Unidos
Instituição/País de afiliação:
Baylor College of Medicine/US
/
Rochester Regional Health/US
/
University of Texas/US
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