Efecto de distintos esquemas de administración de ciclofosfamida en la mortalidad del ratón adulto infectado con virus Junín / [Effect of various schedules of cyclophosphamide administration on the mortality of the adult mouse infected with Junín virus]

ABSTRACT

The object of this paper was to determine the influence of cyclophosphamide immunosuppression on the mortality of 40-45 day old Balb/c mice infected intracerebrally with a pathogenic strain of Junin virus, using different administration schedules. Up to 200 mg/kg of cyclophosphamide were not toxic. Results show that, unlike in other experimental models, three or four 50 mg/kg cyclophosphamide doses given both before and after viral infection were required to break-down resistance to Junin virus (90-96.5