Antibacterial and Cytotoxic Effects of Cyclodextrin-Triazole-Titanium Based Nanocomposite
Braz. arch. biol. technol
;
64: e21190750, 2021. tab, graf
Artigo
em Inglês
| LILACS
| ID: biblio-1249207
ABSTRACT
Abstract In this paper, the antibacterial activity of triazole functionalized cyclodextrin (CD.Click) and cyclodextrin-triazole-titanium based nanocomposite (CD.COM) was evaluated. The results indicated that CD.Click and CD.COM perform a wide range of antibacterial activity against both gram positive (Staphylococcus aureus and Bacillus subtilis) and gram negative (Escherichia coli and Pseudomonas aeruginosa) bacteria. The cytotoxic effect of CD.COM was investigated in vitro on cancerous cell lines (cervical cancer, breast carcinoma and sarcoma osteogenic) and fibroblast cells by MTT assay. The cell viability evaluation confirmed that the growth of cancerous cells is inhibited in a dose and time dependent way without any significant effect on the normal fibroblast cells.
Texto completo:
DisponíveL
Índice:
LILACS (Américas)
Assunto principal:
Triazóis
/
Beta-Ciclodextrinas
Tipo de estudo:
Estudos de avaliação
Idioma:
Inglês
Revista:
Braz. arch. biol. technol
Assunto da revista:
Biologia
Ano de publicação:
2021
Tipo de documento:
Artigo
País de afiliação:
Irã
Instituição/País de afiliação:
Babol University of Medical Sciences/IR
/
Shahrood University of Technology/IR
/
University of Mazandaran/IR
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