A novel prognostic index in patients with resectable esophageal squamous cell carcinoma: fibrinogen/prealbumin ratio
Rev. invest. clín
;
72(1): 46-54, Jan.-Feb. 2020. tab, graf
Artigo
em Inglês
| LILACS
| ID: biblio-1251834
ABSTRACT
ABSTRACT Background:
Fibrinogen (Fib) to albumin (ALB) fibrinogen-to-albumin ratio as a prognostic index for esophageal cancer has been confirmed. A novel prognostic index was initially proposed with fibrinogen to prealbumin ratio (FPR) in patients with resectable esophageal squamous cell carcinoma (ESCC).Objective:
The objective of the study was to study the prognostic role of the novel prognostic index (FPR) in patients with resectable ESCC without any neoadjuvant treatment.Methods:
In this retrospective study, a total of 372 resectable ESCC patients without any neoadjuvant treatment were included. The best cutoff values were selected by the receiver operating characteristic curves. Two Cox regression analyses with forward stepwise (one for categorical variables and the other for continuous variables) were used to evaluate the overall survival (OS) and cancer-specific survival (CSS).Results:
The best cutoff point was 0.014 for FPR. Patients with lower levels of FPR (≤0.014) had better CSS (50.7% vs. 18.0%, p < 0.001) and OS (48.0% vs. 17.6%, p < 0.001) than patients with higher levels of FPR (> 0.014). Multivariate Cox analyses (categorical and continuous) demonstrated that FPR was an independent prognostic factor in CSS (categorical hazard ratio [HR] 2.014, 95% confidence interval [CI] 1.504-2.697, p < 0.001; continuous per 0.01 HR 1.438, 95% CI 1.154-1.793, p = 0.001) and OS (categorical HR 1.964, 95% CI 1.475-2.617, p < 0.001; continuous per 0.01 HR 1.429, 95% CI 1.146-1.781, p = 0.002).Conclusions:
Our study indicated that FPR served as an independent prognostic factor in patients with resectable ESCC.
Texto completo:
DisponíveL
Índice:
LILACS (Américas)
Assunto principal:
Fibrinogênio
/
Pré-Albumina
/
Neoplasias Esofágicas
/
Carcinoma de Células Escamosas do Esôfago
Tipo de estudo:
Estudo observacional
/
Estudo prognóstico
Limite:
Feminino
/
Humanos
/
Masculino
Idioma:
Inglês
Revista:
Rev. invest. clín
Assunto da revista:
Medicina
Ano de publicação:
2020
Tipo de documento:
Artigo
País de afiliação:
China
Instituição/País de afiliação:
University of the Chinese Academy of Sciences/CN
Similares
MEDLINE
...
LILACS
LIS