Therapeutic use of human papillomavirus vaccines in cervical lesions
Rev. invest. clín
;
72(4): 239-249, Jul.-Aug. 2020. tab, graf
Artigo
em Inglês
| LILACS
| ID: biblio-1251861
ABSTRACT
ABSTRACT Human papillomavirus (HPV) has been associated with the development of precancerous lesions of the cervix and cervical cancer (CC). Prophylactic HPV vaccination induces the development of a specific memory immune response that facilitates HPV elimination once the natural infection occurs. At present, in addition to the prophylactic vaccine, therapeutic vaccines are being developed and researched with the aim of inducing an immune response that allows the elimination of HPV-infected cells. The purpose of this study is to describe the current evidence on the use of therapeutic vaccines and their effect on cervical precancerous lesions, to establish recommendations on their clinical use. So far, the studies that have generated results have described a marginal beneficial effect of the prophylactic vaccine in the management of infection and pre-invasive lesions. Based on the evidence, continuing research on the efficacy and safety of therapeutic vaccines for the treatment of cervical intraepithelial lesions is recommended. The use of the HPV prophylactic vaccine as treatment for pre-existing lesions is not advised, but it is recommended to prevent new lesions.
Texto completo:
DisponíveL
Índice:
LILACS (Américas)
Assunto principal:
Lesões Pré-Cancerosas
/
Neoplasias do Colo do Útero
/
Infecções por Papillomavirus
/
Vacinas contra Papillomavirus
Tipo de estudo:
Guia de Prática Clínica
Limite:
Humanos
Idioma:
Inglês
Revista:
Rev. invest. clín
Assunto da revista:
Medicina
Ano de publicação:
2020
Tipo de documento:
Artigo
País de afiliação:
Índia
/
México
Instituição/País de afiliação:
Centro Estatal de Cancerología de Nayarit/MX
/
Centro Médico ABC/MX
/
Hospital General de México Dr. Eduardo Liceaga,/MX
/
Instituto Nacional de Cancerología/MX
/
Instituto Nacional de Perinatología/MX
Similares
MEDLINE
...
LILACS
LIS