Prevention of Radiation Induced Hematological Alterations by Medicinal Plant Rosmarinus Officinalis; in Mice
Afr. J. Tradit. Complement. Altern. Med. (Online)
; (4(2): 165-172, 2007.
Article
em En
| AIM
| ID: biblio-1256121
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ABSTRACT
The modulatory influence of Rosmarinus officinalis (rosemary) leaves extract was investigated in Swiss albino mice at a dose of 3 Gy gamma radiation. For this purpose; adult Swiss albino mice were irradiated with 3 Gy gamma rays in the presence (experimental) or absence (control) of rosemary (1000 mg/kg body wt.). These animals were necropsied and their blood was collected at days 1; 3; 5; 10; 20 and 30 post-irradiation. A decrease in the number of erythrocyte and leucocyte counts; hemoglobin content and hematocrit percentage was scored in the control group; whereas a recovery pattern was recorded in experimental animals and a normal value of hematological parameters were regained by day 30 post-treatment. In irradiated group; glutathione level was registered low in the blood; whereas a significant elevation was estimated in rosemary pre-treated animals. An increase in lipid peroxidation level above normal was evident in serum of irradiated mice; while a significant decrease in such values was noted in rosemary pretreated group. The present study suggests the possible radioprotective ability of rosemary extract
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Índice:
AIM
Assunto principal:
Peroxidação de Lipídeos
/
Rosmarinus
/
Raios gama
/
Glutationa
/
Hematologia
/
Camundongos
Idioma:
En
Revista:
Afr. J. Tradit. Complement. Altern. Med. (Online)
Ano de publicação:
2007
Tipo de documento:
Article