Total Immunoglobulin G and IgG1 Subclass Levels Specific for the MSP-1 19 of Plasmodium falciparum are Different in Individuals with either Processing-Inhibitory; Blocking or Neutral Antibodies
Afr. health sci. (Online)
;
10(2): 106-110, 2010.
Artigo
em Inglês
| AIM
| ID: biblio-1256384
ABSTRACT
Background:
Some MSP-1 19 specific antibodies that inhibit merozoite invasion also inhibit the secondary processing of MSP-1. However the binding of these inhibitory antibodies can be blocked by another group of antibodies; called blocking antibodies; which recognize adjacent or overlapping epitopes; but themselves have no effect on either MSP-1 processing or merozoite invasion. These antibodies have been reported to be present in individuals living in a malaria endemic area.Methods:
Blood samples were obtained from children shown to have processing inhibitory; blocking; and neutral antibodies in a previous study. Enzyme linked immunosorbent assay (ELISA); was used to determine the total IgG; IgM and IgG subtypes.Results:
There was a significant difference in anti-MSP-1 19 IgG; while there was no significant difference in the anti-MSP-1 19 IgM. Only anti MSP-1 19 IgG1; amongst the IgG subtypes was significantly different between the groups.Conclusion:
This study shows that antibodies against MSP-1 are different not only in specificity and function but also in the amount of total IgG and IgG subtype produced
Texto completo:
DisponíveL
Índice:
AIM (África)
Assunto principal:
Plasmodium falciparum
Idioma:
Inglês
Revista:
Afr. health sci. (Online)
Ano de publicação:
2010
Tipo de documento:
Artigo
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