Severe Depression Following a-interferon Usage in a Patient with Chronic Myeloid Leukemia
Afr. health sci. (Online)
;
9(1): 54-56, 2009.
Artigo
em Inglês
| AIM
| ID: biblio-1256538
ABSTRACT
Background:
Chronic myeloid leukaemia (CML); with a median age of 40 years; is one of the commonest haematological malignancies in Nigeria. Cytoreductive agents; which were hitherto the mainstay of treatment; neither induce cytogenetic nor haematologic remission. Alpha-interferon (a-IFN); an endogenous glycoprotein with cytotoxic and natural killer cell enhancer effects has been found to induce haematologic and cytogenetic remission in patients with CML; but neuro- psychiatric complications of a -interferon (a-IFN) usage were not reported in Nigeria.Objective:
To report a case of deliberate self-harm in University Lecturer as a side effect of a-IFN in the treatment of CML.Method:
Clinical and laboratory follow up of a patient receiving a-IFN in the management of CML from the time of diagnosis of CML to the point of loss of contact.Result:
Severe depression is a complication that may adversely influence the clinical outcome of a-IFN usage Conclusions/Recommendations:
Although interferon related depression is uncommon; it is suggested that pre-therapy interferon assays and neuro-psychiatric assessment are carried out in prospective users of a-IFN
Texto completo:
DisponíveL
Índice:
AIM (África)
Assunto principal:
Leucemia
/
Interferons
/
Depressão
Tipo de estudo:
Guia de Prática Clínica
Idioma:
Inglês
Revista:
Afr. health sci. (Online)
Ano de publicação:
2009
Tipo de documento:
Artigo
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