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Determination of the optimal EDTA and Pentostam concentration in the treatment of Leishmania donovani-infected laboratory animal rodent models
Abok, K; Anjili, C. O; Githure, J. I; Koech, D. K; Mbati, P. A; Orago, A. S.
  • Abok, K; s.af
  • Anjili, C. O; s.af
  • Githure, J. I; s.af
  • Koech, D. K; s.af
  • Mbati, P. A; s.af
  • Orago, A. S; s.af
Afr. j. health sci ; 2(1): 254-255, 1995.
Artigo em Inglês | AIM | ID: biblio-1257040
ABSTRACT
The objective of this study was to undertake a dose response study to determine the optimal Pentostam and Ethylenediamine tetraacetic acid (EDTA) dose that could be used in the treatment of leishmania-infected golden hamsters or BALB/c mice for a period of 30 days. This pilot experiment was done using only one chelator; EDTA and the toxicity results obtained from this experiment formed the basis for the selection of a suitable chelator dose of this class for the future treatment of leishmania-infected laboratory animal rodent models. It is concluded that Pentostam concentrations beyond 600 mg/kg are highly toxic to mice and therefore unsuitable for use. Although Pentostam have been used to treat leishmania-infected BALB/c mice; this study has shown that a concentration of 100 mg/KG/day is the most suitable dose for use in the treatment of rodent animal models
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Índice: AIM (África) Assunto principal: Leishmaniose / Terapia por Quelação / Animais Idioma: Inglês Revista: Afr. j. health sci Ano de publicação: 1995 Tipo de documento: Artigo

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Índice: AIM (África) Assunto principal: Leishmaniose / Terapia por Quelação / Animais Idioma: Inglês Revista: Afr. j. health sci Ano de publicação: 1995 Tipo de documento: Artigo