Determination of the optimal EDTA and Pentostam concentration in the treatment of Leishmania donovani-infected laboratory animal rodent models
Afr. j. health sci
;
2(1): 254-255, 1995.
Artigo
em Inglês
| AIM
| ID: biblio-1257040
ABSTRACT
The objective of this study was to undertake a dose response study to determine the optimal Pentostam and Ethylenediamine tetraacetic acid (EDTA) dose that could be used in the treatment of leishmania-infected golden hamsters or BALB/c mice for a period of 30 days. This pilot experiment was done using only one chelator; EDTA and the toxicity results obtained from this experiment formed the basis for the selection of a suitable chelator dose of this class for the future treatment of leishmania-infected laboratory animal rodent models. It is concluded that Pentostam concentrations beyond 600 mg/kg are highly toxic to mice and therefore unsuitable for use. Although Pentostam have been used to treat leishmania-infected BALB/c mice; this study has shown that a concentration of 100 mg/KG/day is the most suitable dose for use in the treatment of rodent animal models
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Índice:
AIM (África)
Assunto principal:
Leishmaniose
/
Terapia por Quelação
/
Animais
Idioma:
Inglês
Revista:
Afr. j. health sci
Ano de publicação:
1995
Tipo de documento:
Artigo
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