Antimicrobial suseptibility of neisserria gonorrhoeae isolated from patients attending various clinics in Pambeguwa, Kaduna State

ABSTRACT

Abstract Antimicrobial resistant strains of gonococcal isolates have spread in many developing countries. In most African countries, the susceptibility of Neisseria gonorrhoeae is rarely tested. The antimicrobial susceptibility of one hundred and eight (108) Neisseria gonorrhoeae was therefore determined. Of the 108 isolates tested, 80 (74.07%) were resistant to penicillin, 74 (68.5%) were resistant to ampicillin. The resistance profiles for the remaining antibiotics tested were as follows Erythromycin (58.3%), Tetracycline (62%) and gentamicin (25.9%). All the isolates were susceptible to ceftriaxone, cefuroxime and ofloxacin. Of the 80 penicillin resistant strains, 65 (81.3%) were penicillinase producing Neisseria gonorrhoeae (PPNG). The Minimum Inhibitory Concentration (MIC) of Penicillin against 9 gonococcal isolates, Ampicillin against 5 Neisseria gonorrhoeae isolates and Tetracycline against 2 gonococcal isolates was 32.0µg/ml. A total of 108 isolates were susceptible to 0.125µg/ml of ceftriaxone, cefuroxime and ofloxacin respectively. The high prevalence of PPNG and multiple drug resistance strains of Neisseria gonorrhoeae is associated with self-medication and sexual interaction between commercial sex workers (CSWs) resident in Pambeguwa and the long-distance truck drivers. Antimicrobial susceptibility test should be carried out on every gonococcal isolate obtained to ensure effective therapy. The present study was undertaken to assess the antimicrobial susceptibility of gonococcal isolates recovered from patients in Pambeguwa,Kaduna state, Nigeria