Evaluation of the analgesic activity of the methanolic stem bark extract of dialium guineense (wild)
Ann. med. health sci. res. (Online)
;
1(1): 55-62, 2011. ilus
Artigo
em Inglês
| AIM
| ID: biblio-1259204
ABSTRACT
Background:
Dialium guineense is a medicinal plant used by some communities of Enugu-Ezike in Enugu State; Nigeria for treatment of fever; headache and other diverse ailments.Objectives:
The present study evaluated the analgesic activity of the methanolic stem bark extract of the plant.Method:
Acetic acid-induced abdominal constriction or writhing; tail immersion and hot plate analgesic models in albino Wistar mice were used for the study. Three test doses (250; 500; 1000 mg/kg body weight) of the extract were administered orally by gastric gavage. The activity was compared with a standard reference drug; acetylsalicylic acid (aspirin) (400 mg/kg) and negative control. The results were analysed by SPSS version 17 using ANOVA and Post Hoc Duncan.Result:
In the acetic acid-induced writhing reflex model; D. guineense extract and the reference drug significantly (P =0.014 - 0.002) decreased the mean total number of abdominal constriction in the mice in a dose dependent fashion. The percentage inhibition of the abdominal constriction reflex was increased dose dependently from 0in the negative control group to 71at the highest dose of the extract (1000mg/kg). In the tail immersion model the extract at the dose of 1000 mg/kg significantly (P = 0. 048) increased the pain reaction time (PRT) while in hot plate model the extract and drug also significantly (P = 0.048 - 0.05) increased the mean PRT at the doses of 500 and 1000 mg/kg. The dose of 250 mg/kg showed no analgesic activity in tail immersion and hot plate models.Conclusion:
Dialium guineense demonstrated significant analgesic activity that may be mediated through peripheral pain mechanism
Texto completo:
DisponíveL
Índice:
AIM (África)
Assunto principal:
Plantas Medicinais
/
Aspirina
/
Febre
/
Cefaleia
/
Analgésicos
/
Nigéria
País/Região como assunto:
África
Idioma:
Inglês
Revista:
Ann. med. health sci. res. (Online)
Ano de publicação:
2011
Tipo de documento:
Artigo
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