Correlation between prostate volume and prostate-specific antigen in patients diagnosed with benign prostatic hyperplasia

ABSTRACT

Background: Prostate volume (PV) and serum prostate specific antigen (PSA) have been consistently linked to benign prostatic hyperplasia (BPH) disease progression especially when prostate volumes are >30mls and PSA>1.5ng/ml. PSA is produced by the ductal epithelial cells of the prostate. Understanding the natural history of prostate diseases requires knowledge of prostate volume and PSA. Objective: We set out to determine the correlation between prostate volume and PSA in our cohorts of men diagnosed with BPH. Methodology: Information from the case notes of 120 patients were retrieved including history, physical examination and result of relevant investigations. Data collated were analyzed using the statistical package for social sciences (SPSS) version 20.0 software. Results: Mean age of the patients was 64.95±9.22 years while mean PV and PSA were respectively 70.20±52.01mls and 4.58±3.32ng/ml. Correlation between PV and PSA was statistically significant r=.407, P value was set at <.05. Conclusion: We concluded that PV and serum PSA levels have a direct relationship