Histomorphologic Alterations of the Cerebellum of Wistar Rats following Amodiaquine Plus Artesunate Administration
Internet Journal of Medical Update
;
4(2): 15-18, 2009.
Artigo
em Inglês
| AIM
| ID: biblio-1263128
ABSTRACT
Amodiaquine and artesunate are two antimalarial drugs sold in combination as Larimalr'. This drug is a very effective artemisinin-base combination. This study was to access the effects of amodiaquine and artesunate combination on the histology of the cerebellum. Twenty adult Wistar rats weighing between 150-180g were divided into four groups (A; B; C and D) of five animals each. Group A served as the control and the animals received distilled water; while group B received 8.75+2.86mg/kg of amodiaquine and artesunate combination for three days; group C received 8.75+2.86mg/kg of amodiaquine and artesunate combination for six days and group D received 17.50+5.71mg/kg of amodiaquine and artesunate combination for three days. Histological sections showed destruction of the Purkinje cortical layers in group B; with increased destructions in groups C and D compared to the control. These results reveal that amodiaquine and artesunate combination causes histological alterations; which were dose and time dependent and these may result in cerebellar dysfunction
Texto completo:
DisponíveL
Índice:
AIM (África)
Assunto principal:
Ratos
/
Cerebelo
/
Combinação de Medicamentos
/
Amodiaquina
/
Histologia
Idioma:
Inglês
Revista:
Internet Journal of Medical Update
Ano de publicação:
2009
Tipo de documento:
Artigo
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