Congenital heart disease in a cohort of Sudanese patients with cleft defects
Khartoum Medical Journal
; 12(1): 1558-1563, 2019. ilus
Article
em En
| AIM
| ID: biblio-1264632
Biblioteca responsável:
CG1.1
ABSTRACT
Background and objectives:
Cleft defects are among the most visible congenital defects worldwide and congenital heart disease (CHD) being one of the most common associated anomalies. This study aimed to assess the prevalence of CHD among a cohort of Sudanese patients with cleft lip and/or palate. Patients andMethods:
All patients who presented to Soba University Hospital with cleft lip and/or palate from March 2009 to March 2015 were included.Results:
Out of 381 patients included; 168 patients (44%) had cleft lip and palate (CLP), 156 (41%) had cleft lip (CL) and isolated cleft palate (CP) was found in 57 patients (15%). Facial dysmorphic features were identified in 57 (15%) and cardiac defects in 42 (11%) patients. Ventricular septal defect (VSD) was diagnosed in 16 patients (38%), and ASD in 12 (30.9%). Other macroscopic anomalies were identified in 57 patients (15%) and were associated with CHD (P<0.001). Significant association was found between the type of cleft and CHD (P<0.002), as cardiac defects were maximally observed among CP cases (21%) followed by CLP cases (13%) then CL cases (5.12%). Significant association was also found between facial dysmorphic occurrence and CHD (P < 0.001).Conclusion:
CHD is a common anomaly in cleft population. The pattern of CHD is consistent with the literature with VSD being the most frequent. The cardiac defects are most prevalent in CP group. Echocardiography is justified for screening of CHD due to the relatively higher incidence of CHD among clefts patients than in general population
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Índice:
AIM
Assunto principal:
Sudão
/
Efeito de Coortes
/
Doença
/
Cardiopatias Congênitas
Tipo de estudo:
Risk_factors_studies
País/Região como assunto:
Africa
Idioma:
En
Revista:
Khartoum Medical Journal
Ano de publicação:
2019
Tipo de documento:
Article