Dose-dependent amelioration of gentamicin-Induced nephrotoxicity in adult swiss albino rats by vitamin B-complex - A preliminary study
Trop. j. pharm. res. (Online)
; 8(2): 111-116, 2009. tables, figures
Article
em En
| AIM
| ID: biblio-1273112
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ABSTRACT
Purpose:
To evaluate the effect of vitamin B-complex on the nephrotoxicity of gentamicin in an established rat model.Methods:
Adult Swiss albino rats weighing 170±20g were divided into 4 groups of 4 rats each. Each group was given one of the following placebo injection (Control), 80mg/kg of gentamicin sulphate alone or with 1.5ml/kg/3ml/kg body weight of vitamin B-complex (intramuscular) containing 10mg thiamine, 1.5mg riboflavin and 1.0mg pyridoxal-6-phosphate per ml.Results:
In the Swiss albino rats, daily intramuscular 80mg/kg gentamicin sulphate significantly (p<0.05) and consistently produced biochemical signs of nephrotoxicity after 5 days. Also, 1.5 ml/kg of B-complex significantly (p<0.05) ameliorated the rate and extent of increase in serum urea and creatine while 3ml/kg of the same drug completely prevented the increase in serum urea and creatine in this model.Conclusion:
Vitamin B-complex dose-dependently ameliorated gentamicin-induced nephrotoxicity in adult Swiss albino rats when given intramuscularly. This finding may have important clinical utilityPalavras-chave
Texto completo
- https://indexmedicus.afro.who.int/iah/fulltext/Dose Dependent Amelioration of Gentamicin Induced Nephrotoxicity in Adult Swiss Albino Rats by Vitamin B comDose Dependent Amelioration of Gentamicin Induced Nephrotoxicity in Adult Swiss Albino Rats by Vitamin Bcomplex A Preliminary Studyplex A Preliminary Study.pdf
- file:///Z:/TJPR/vol%208%20n2/dose-dependent%20111-116.pdf
- https://fi-admin.bvsalud.org/document/view/rdafd
Texto completo:
1
Índice:
AIM
Assunto principal:
Ureia
/
Complexo Vitamínico B
/
Gentamicinas
/
Creatina
/
Nigéria
Tipo de estudo:
Clinical_trials
/
Prognostic_studies
Limite:
Humans
País/Região como assunto:
Africa
Idioma:
En
Revista:
Trop. j. pharm. res. (Online)
Ano de publicação:
2009
Tipo de documento:
Article