Histomorphometric analysis of liver biopsies of treated patients with Gaucher disease type 1
Autops. Case Rep
;
11: e2021306, 2021. tab, graf
Artigo
em Inglês
| LILACS
| ID: biblio-1285400
ABSTRACT
Gaucher disease (GD) is an autosomal recessive lysosomal disorder caused by a disturbance in the metabolism of glucocerebroside in the macrophages. Most of its manifestations - hepatosplenomegaly, anemia, thrombocytopenia, and bone pain - are amenable to a macrophage-target therapy such as enzyme replacement. However, there is increasing evidence that abnormalities of the liver persist despite the specific GD treatment. In this work, we adapted histomorphometry techniques to the study of hepatocytes in GD using liver tissue of treated patients, developing the first morphometrical method for canalicular quantification in immunohistochemistry-stained liver biopsies, and exploring histomorphometric characteristics of GD. This is the first histomorphometric technique developed for canalicular analysis on histological liver biopsy samples.
Texto completo:
DisponíveL
Índice:
LILACS (Américas)
Assunto principal:
Citometria por Imagem
/
Doença de Gaucher
Limite:
Humanos
Idioma:
Inglês
Revista:
Autops. Case Rep
Assunto da revista:
Anatomia
/
Patologia Cl¡nica
/
Patologia Legal
Ano de publicação:
2021
Tipo de documento:
Artigo
País de afiliação:
Brasil
/
Estados Unidos
Instituição/País de afiliação:
Hospital de Clínicas de Porto Alegre/BR
/
Mayo Clinic/US
/
Universidade Federal do Rio Grande do Sul/BR
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