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Subacute combined degeneration of the spinal cord with concomitant autoimmune disease: report of 2 cases
Jiang, Tian-Fang; Zheng, Jia; Chen, Xu.
  • Jiang, Tian-Fang; Shanghai Eighth Peoples Hospital Affiliated to Jiang Su University. Department of Neurology. CN
  • Zheng, Jia; Shanghai Eighth Peoples Hospital Affiliated to Jiang Su University. Department of Neurology. CN
  • Chen, Xu; Shanghai Eighth Peoples Hospital Affiliated to Jiang Su University. Department of Neurology. CN
Braz. j. med. biol. res ; 54(10): e11355, 2021. graf
Artigo em Inglês | LILACS | ID: biblio-1285647
ABSTRACT
The etiology of subacute combined degeneration (SCD) of the spinal cord is closely associated with vitamin B12 (VitB12) deficiency. The clinical manifestations of SCD are complex and vary substantially. Due to some SCD patients with atypical manifestations and concomitant autoimmune disorders, the probability of misdiagnosis and missed diagnosis is still relatively high in the early stage. We report the cases of two patients who were missed or misdiagnosed at another hospital because of the normal initial VitB12 level and partial overlap of clinical manifestations, finally diagnosed as SCD with atypical manifestations and concomitant autoimmune disorders, pharyngeal-cervical-brachial Guillain-Barre syndrome in Case 1 and SCD with autoimmune thyroiditis in Case 2. After undergoing corresponding treatment, death was reported in Case 1 and improvement in Case 2. Analysis of the clinical manifestations and investigation of the underlying pathogenesis in such patients could help improve the rate of early diagnosis and allow timely treatment of SCD, thereby preventing disease progression and poor clinical outcomes.
Assuntos


Texto completo: DisponíveL Índice: LILACS (Américas) Assunto principal: Doenças Autoimunes / Degeneração Combinada Subaguda Tipo de estudo: Estudo de rastreamento Limite: Humanos Idioma: Inglês Revista: Braz. j. med. biol. res Assunto da revista: Biologia / Medicina Ano de publicação: 2021 Tipo de documento: Artigo País de afiliação: China Instituição/País de afiliação: Shanghai Eighth Peoples Hospital Affiliated to Jiang Su University/CN

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Texto completo: DisponíveL Índice: LILACS (Américas) Assunto principal: Doenças Autoimunes / Degeneração Combinada Subaguda Tipo de estudo: Estudo de rastreamento Limite: Humanos Idioma: Inglês Revista: Braz. j. med. biol. res Assunto da revista: Biologia / Medicina Ano de publicação: 2021 Tipo de documento: Artigo País de afiliação: China Instituição/País de afiliação: Shanghai Eighth Peoples Hospital Affiliated to Jiang Su University/CN