Therapeutic applications based on cannabinoids action / Aplicaciones terapéuticas por acción de los cannabinoides
Gac. méd. Méx
;
155(3): 307-318, may.-jun. 2019. tab
Artigo
em Inglês
| LILACS
| ID: biblio-1286504
ABSTRACT
The interest on cannabinoids became evident between the 1940 and 1950 decades. Although the active substance of the plant was not known, a series of compounds with cannabinomimetic activity were synthesized, which were investigated in animals and clinically. The most widely tested was Δ6α, 10α-THC hexyl. Δ6α, 10α-THC dimethylheptyl (DMHP) antiepileptic effects were studied in several children, with positive results being obtained in some cases. DMHP differs from sinhexyl in that its side chain is DMHP instead of n-hexyl. The first cannabinoid isolated from Cannabis sativa was cannabinol, although its structure was correctly characterized several years later. Cannabidiol was isolated some years later and was subsequently characterized by Mechoulam and Shvo. In 2013, the National Academy of Medicine and the Faculty of Medicine of the National Autonomous University of Mexico, through the Seminar of Studies on Entirety, decided to carry out a systematic review on a subject that is both complex and controversial: the relationship between marijuana and health. In recent years, studies have been conducted with cannabis in several diseases: controlled clinical trials on spasticity in multiple sclerosis and spinal cord injury, chronic, essentially neuropathic, pain, movement disorders (Gilles de Latourette, dystonia, levodopa dyskinesia), asthma and glaucoma, as well as non-controlled clinical trials on Alzheimers disease, neuroprotection, intractable hiccups, epilepsy, alcohol and opioid dependence and inflammatory processes.
Texto completo:
DisponíveL
Índice:
LILACS (Américas)
Assunto principal:
Canabidiol
/
Canabinoides
/
Cannabis
Limite:
Animais
/
Humanos
Idioma:
Inglês
Revista:
Gac. méd. Méx
Assunto da revista:
Medicina
Ano de publicação:
2019
Tipo de documento:
Artigo
País de afiliação:
México
Instituição/País de afiliação:
Academia Nacional de Medicina/MX
/
Secretaría de Salud/MX
/
Universidad Nacional Autónoma de México/MX
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