Your browser doesn't support javascript.
loading
Relationship of the low-density lipoprotein (LDL)/high-density lipoprotein (HDL) index with antioxidant enzymes and with the oxLDL/HDL index
Zamora-Ginez, Irma; Baez-Duarte, Blanca Guadalupe; Nieva-Vazquez, Adriana; García-Aragón, Karla Hilsen; Monjaraz-Guzmán, Eduardo; Mendoza-Carrera, Francisco; Meneses-Zamora, Paola; Flores-Blanco, Claudia Valeria; Luna-De Jesús, Karina.
  • Zamora-Ginez, Irma; Benemérita Universidad Autónoma de Puebla. Faculty of Medicine. Puebla. MX
  • Baez-Duarte, Blanca Guadalupe; Benemérita Universidad Autónoma de Puebla. Faculty of Medicine. Puebla. MX
  • Nieva-Vazquez, Adriana; Benemérita Universidad Autónoma de Puebla. Southern Regional Complex. Puebla. MX
  • García-Aragón, Karla Hilsen; Universidad Autónoma del Estado de Morelos. Morelos. MX
  • Monjaraz-Guzmán, Eduardo; Benemérita Universidad Autónoma de Puebla. Physiology Unit. Puebla. MX
  • Mendoza-Carrera, Francisco; Instituto Mexicano del Seguro Social. Center of Biomedical Research of the West. Molecular Medicine Division. MX
  • Meneses-Zamora, Paola; Benemérita Universidad Autónoma de Puebla. Faculty of Medicine. Puebla. MX
  • Flores-Blanco, Claudia Valeria; Benemérita Universidad Autónoma de Puebla. Faculty of Medicine. Puebla. MX
  • Luna-De Jesús, Karina; Instituto Politécnico Nacional. Center of Research on Applied Biotechnology. MX
Gac. méd. Méx ; 155(5): 453-457, Sep.-Oct. 2019. tab
Artigo em Inglês | LILACS | ID: biblio-1286542
ABSTRACT
Introduction: The low-density lipoprotein (LDL)/high-density lipoprotein (HDL) index is a predictive factor for atherosclerosis, which is associated with oxidative modifications. Objective: To assess the association of the index with oxidative stress markers. Methods: 444 subjects were included and were clinically, anthropometrically and biochemically characterized; superoxide dismutase, glutathione peroxidase 3 (GPx3), magnesium and oxidized LDL (oxLDL) index (oxLDL/HDL) were quantified. Results: A decrease of 1.014 units in the LDL/HDL index was associated with a superoxide dismutase increase of 1 unit/mL (p = 0.030), while a decrease of 0.023 units was associated with a GPx3 increase of 1 nmol/min/mL (p < 0.0005). An increase of one unit in the index was associated with an increase of 0.831 in the oxLDL/HDL index (p < 0.05). After controlling for the effect of gender, age, smoking, obesity and insulin resistance, a reduction of 0.001 per index unit was associated with an increase of 1 µg/g of magnesium in the nails (p = 0.020). Conclusions: The LDL/HDL index shows an inverse relationship with the antioxidant status and a direct relationship with oxidation status, regardless of other cardiovascular and oxidative stress risk factors.
Assuntos


Texto completo: DisponíveL Índice: LILACS (Américas) Assunto principal: Superóxido Dismutase / Estresse Oxidativo / Glutationa Peroxidase / Lipoproteínas HDL / Lipoproteínas LDL Tipo de estudo: Estudo observacional / Estudo de prevalência / Estudo prognóstico / Fatores de risco Limite: Adulto / Feminino / Humanos / Masculino Idioma: Inglês Revista: Gac. méd. Méx Assunto da revista: Medicina Ano de publicação: 2019 Tipo de documento: Artigo País de afiliação: México Instituição/País de afiliação: Benemérita Universidad Autónoma de Puebla/MX / Instituto Mexicano del Seguro Social/MX / Instituto Politécnico Nacional/MX / Universidad Autónoma del Estado de Morelos/MX

Similares

MEDLINE

...
LILACS

LIS


Texto completo: DisponíveL Índice: LILACS (Américas) Assunto principal: Superóxido Dismutase / Estresse Oxidativo / Glutationa Peroxidase / Lipoproteínas HDL / Lipoproteínas LDL Tipo de estudo: Estudo observacional / Estudo de prevalência / Estudo prognóstico / Fatores de risco Limite: Adulto / Feminino / Humanos / Masculino Idioma: Inglês Revista: Gac. méd. Méx Assunto da revista: Medicina Ano de publicação: 2019 Tipo de documento: Artigo País de afiliação: México Instituição/País de afiliação: Benemérita Universidad Autónoma de Puebla/MX / Instituto Mexicano del Seguro Social/MX / Instituto Politécnico Nacional/MX / Universidad Autónoma del Estado de Morelos/MX