Soluble insulin receptor and metabolic syndrome
Gac. méd. Méx
;
155(5): 500-503, Sep.-Oct. 2019. graf
Artigo
em Inglês
| LILACS
| ID: biblio-1286550
ABSTRACT
The metabolic syndrome describes a group of signs that increase the likelihood for developing type 2 diabetes mellitus, cardiovascular diseases and some types of cancer. The action of insulin depends on its binding to membrane receptors on its target cells. We wonder if blood insulin could travel bound to proteins and if, in the presence of hyperinsulinemia, a soluble insulin receptor might be generated. We used young adult Wistar rats (which have no predisposition to obesity or diabetes), whose drinking water was added 20 % of sugar and that were fed a standard diet ad libitum for two and six months. They were compared with control rats under the same conditions, but that had running water for consumption. At two months, the rats developed central obesity, moderate hypertension, high triglyceride levels, hyperinsulinemia, glucose intolerance and insulin resistance, i.e., metabolic syndrome. Electrophoresis of the rats plasma proteins was performed, followed by Western Blot (WB) for insulin and for the outer portion of the insulin receptor. The bands corresponding to insulin and to the receptor external part were at the same molecular weight level, 25-fold higher than that of free insulin. We demonstrated that insulin, both in control animals and in those with hyperinsulinemia, travels bound to the receptor outer portion (ectodomain), which we called soluble insulin receptor, and that is released al higher amounts in response to plasma insulin increase; in rats with metabolic syndrome and hyperinsulinemia, plasma levels are much higher than in controls. Soluble insulin receptor increase in blood might be an early sign of metabolic syndrome.
Texto completo:
DisponíveL
Índice:
LILACS (Américas)
Assunto principal:
Resistência à Insulina
/
Receptor de Insulina
/
Síndrome Metabólica
/
Hiperinsulinismo
/
Insulina
Tipo de estudo:
Estudo de etiologia
Limite:
Animais
/
Humanos
Idioma:
Inglês
Revista:
Gac. méd. Méx
Assunto da revista:
Medicina
Ano de publicação:
2019
Tipo de documento:
Artigo
País de afiliação:
México
Instituição/País de afiliação:
Universidad Nacional Autónoma de México/MX
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