Small airway disease in COPD associated to biomass exposure
Rev. invest. clín
;
71(1): 70-78, Jan.-Feb. 2019. tab, graf
Artigo
em Inglês
| LILACS
| ID: biblio-1289671
ABSTRACT
Abstract Chronic obstructive pulmonary disease (COPD) is a complex and heterogeneous entity that may result from different causative agents and risk factors and may follow diverse clinical courses, including COPD secondary to biomass smoke exposure. At present, this phenotype is becoming more important for two reasons first, because at least almost half of the worlds population is exposed to biomass smoke, and second, because the possibility of it being diagnosed is increasing. Biomass smoke exposure COPD affects primarily women and is related with insults to the airways occurred during early life. Although constituents of biomass smoke and tobacco smoke are similar, the physiopathological changes they induce differ depending not only on the chemical composition (related with the type of fuel used) but also on the particle size and the inhalation pattern. Evidence has shown that biomass smoke exposure affects the airway, predominantly the small airways causing anthracofibrosis and peribronchiolar fibrosis changes that will clinically translate into chronic bronchitis symptoms, with a high impact on the quality of life. In this review, we focus especially on the main epidemiological and clinical differences between COPD secondary to biomass exposure and COPD caused by tobacco exposure.
Texto completo:
DisponíveL
Índice:
LILACS (Américas)
Assunto principal:
Fumaça
/
Biomassa
/
Doença Pulmonar Obstrutiva Crônica
Tipo de estudo:
Estudo de etiologia
/
Fatores de risco
Limite:
Feminino
/
Humanos
/
Masculino
Idioma:
Inglês
Revista:
Rev. invest. clín
Assunto da revista:
Medicina
Ano de publicação:
2019
Tipo de documento:
Artigo
País de afiliação:
Colômbia
/
México
Instituição/País de afiliação:
Fundación Médica Sur/MX
/
Instituto Nacional de Enfermedades Respiratorias Ismael Cosío Villegas/MX
/
La Sabana University/CO
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