Association of bone mineral density with chronic obstructive pulmonary disease in postmenopausal women
Rev. invest. clín
;
71(3): 204-210, May.-Jun. 2019. tab, graf
Artigo
em Inglês
| LILACS
| ID: biblio-1289688
ABSTRACT
Abstract Background Osteoporosis (OP) is common in patients with chronic obstructive pulmonary disease (COPD). The relationship between OP and COPD has been primarily studied in male patients, and few reports are available in postmenopausal women. Objective The purpose of this study was to investigate the association between bone mineral density (BMD) and COPD in postmenopausal women. Methods This cross-sectional study included 133 clinically stable female ex-smokers with confirmed COPD, and 31 age-matched ex-smoker female controls. We analyzed groups according to their airway obstruction category. BMD was measured on dual-energy X-ray absorptiometry images of the left femoral neck. Results Patients with COPD had lower T-scores and higher prevalence of osteopenia/OP than the control group. In the COPD group, the airway obstruction category was significantly associated with the T-score after adjustment for confounders. Multivariate logistic regression analysis showed COPD was an independent marker for increased risk of osteopenia/OP in postmenopausal women. Conclusions COPD and airway obstruction category were strongly related to BMD. Postmenopausal women with COPD, especially those with severe airway obstruction, had a higher prevalence rate and a higher risk of osteopenia and OP than female controls without COPD.
Texto completo:
DisponíveL
Índice:
LILACS (Américas)
Assunto principal:
Densidade Óssea
/
Osteoporose Pós-Menopausa
/
Pós-Menopausa
/
Doença Pulmonar Obstrutiva Crônica
Tipo de estudo:
Estudo de etiologia
/
Estudo observacional
/
Estudo de prevalência
/
Fatores de risco
Limite:
Idoso
/
Feminino
/
Humanos
Idioma:
Inglês
Revista:
Rev. invest. clín
Assunto da revista:
Medicina
Ano de publicação:
2019
Tipo de documento:
Artigo
País de afiliação:
China
Instituição/País de afiliação:
Peoples Hospital of Xinjiang Uygur Autonomous Region/CN
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