Exploratory analysis of polygenic risk scores for psychiatric disorders: Applied to dual diagnosis
Rev. invest. clín
;
71(5): 321-329, Sep.-Oct. 2019. tab, graf
Artigo
em Inglês
| LILACS
| ID: biblio-1289702
ABSTRACT
Background Concurrence of substance use disorders (SUDs) is high in individuals with psychiatric illnesses; more importantly, individuals with both disorders (dual diagnosis) have more severe symptoms. Psychiatric disorders have been proposed to share a genetic susceptibility with SUDs. To explore this shared genetic susceptibility, we analyzed whether any of the polygenic risk scores (PRSs) for psychiatric disorders could be associated to dual diagnosis in patients with schizophrenia (SCZ) or bipolar disorder (BD). Methods We included 192 individuals of Mexican ancestry: 72 with SCZ, 53 with BD, and 67 unrelated controls without psychiatric disorders. We derived calculations of PRS for autism spectrum disorders, attention-deficit/hyperactive disorder, BD, major depression, and SCZ using summary genome-wide association statistics previously published. Results We found that dual diagnosis had a shared genetic susceptibility with major depressive disorder (MDD) and SCZ; furthermore, in individuals with BD, dual diagnosis could be predicted by PRS for MDD. Conclusions Our results reinforce the notion that individuals with dual diagnosis have a higher genetic susceptibility to develop both disorders. However, analyses of larger sample sizes are required to further clarify how to predict risks through PRS within different populations.
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Índice:
LILACS (Américas)
Assunto principal:
Esquizofrenia
/
Transtorno Bipolar
/
Transtornos Relacionados ao Uso de Substâncias
/
Transtornos Mentais
Tipo de estudo:
Estudo diagnóstico
/
Estudo de etiologia
/
Estudo prognóstico
/
Fatores de risco
Limite:
Adulto
/
Feminino
/
Humanos
/
Masculino
País/Região como assunto:
México
Idioma:
Inglês
Revista:
Rev. invest. clín
Assunto da revista:
Medicina
Ano de publicação:
2019
Tipo de documento:
Artigo
País de afiliação:
México
/
Estados Unidos
Instituição/País de afiliação:
Grupo de Estudios Médicos y Familiares Carracci/MX
/
Instituto Nacional de Cancerología/MX
/
Instituto Nacional de Medicina Genómica/MX
/
Texas Tech University/US
/
Universidad Autónoma de Nuevo León/MX
/
Universidad Juárez Autónoma de Tabasco/MX
/
Universidad Nacional Autónoma de México/MX
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