microRNAs y diabetes tipo 1 / microRNAs and type 1 diabetes

ABSTRACT

The worldwide increased incidence of type 1 diabetes (T1D) and the decreased genotypes that confer increased risk to T1D indicate a strong environmental impact on the disease. These mechanisms could occur through epigenetic modifications that operate on several gene expression patterns (methylation and acetylation, among others). An alternative mechanism of gene expression inhibition are the microRNAs families. These small noncoding RNAs bind the of mRNAs, downregulating and can downregulate the expression of multiple genes. In this review we discussed the role of certain miRNAs in three characteristics observed in T1D, such as inflammation, autoimmunity and apoptosis.