Effect of calcium dobesilate in preventing contrast-induced nephropathy in patients with diabetes and chronic kidney disease
Clinics
;
76: e2942, 2021. tab, graf
Artigo
em Inglês
| LILACS
| ID: biblio-1345813
ABSTRACT
OBJECTIVES: This study assessed the protective effect of calcium dobesilate against contrast-induced nephropathy (CIN) after coronary angiography (CAG) or percutaneous coronary intervention (PCI) in patients with diabetes and chronic kidney disease (CKD). METHODS: A total of 130 patients with diabetes and CKD estimated glomerular filtration rate: 30-90 mL/min/1.73m2 were enrolled and included in the analysis. They were divided into experimental (n=65) and control groups (n=65). Patients in the experimental group were administered oral calcium dobesilate (500 mg) three times daily for 2 days before and 3 days after the procedure. The serum creatinine (SCr), cystatin C (Cys C), and neutrophil gelatinase-associated lipocalin (NGAL) levels were measured before and after the procedure. RESULTS: The mean SCr level at 24h after the procedure was found to be significantly lower in the experimental group than in the control group (79.1±19.6 μmol/L vs. 87.0±19.3 μmol/L, p=0.023). However, the Cys C and NGAL levels were not significantly different between the two groups at all measurement time points (all p>0.05). The incidence of CIN defined by the SCr level was significantly lower in the experimental group than in the control group (3 [4.6%] vs. 13 [20.0%], p=0.017). However, the incidence of CIN defined by the Cys C level was not statistically different between the two groups (7 [10.8%] vs. 7 [10.8%], p=1.000). CONCLUSIONS: This study revealed that calcium dobesilate has no preventive effect against CIN in patients with diabetes and CKD.
Texto completo:
DisponíveL
Índice:
LILACS (Américas)
Assunto principal:
Dobesilato de Cálcio
/
Diabetes Mellitus
/
Insuficiência Renal Crônica
/
Intervenção Coronária Percutânea
/
Nefropatias
Limite:
Humanos
Idioma:
Inglês
Revista:
Clinics
Assunto da revista:
Medicina
Ano de publicação:
2021
Tipo de documento:
Artigo
País de afiliação:
China
/
Coréia do Sul
Instituição/País de afiliação:
Korea University Guro Hospital/KR
/
The Second Hospital of Tianjin Medical University/CN
/
the Second Hospital of Tianjin Medical University/CN
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