Comparative assessment of effect of malt with different bud length on prolactin in hyperprolactinemia rat
Braz. J. Pharm. Sci. (Online)
;
57: e18104, 2021. tab, graf
Artigo
em Inglês
| LILACS
| ID: biblio-1350241
ABSTRACT
Malt is the mature fruit of Hordeum vulgare L. after germination and drying and has been applied for treatment female abnormal galactorrhea. Previous studies have showed total alkaloids in malt have anti-HPRL effect. However, total alkaloids of malt change with the growth cycle, and the specified levels of total alkaloids in different bud length of malt have not been decided. To determine the definitive level of total alkaloids in different buds of malt and the most suitable bud length for clinical application by comparing effects on hyperprolactinemia rat. During the budding of malt, the content of total alkaloids first increased and then decreased, and it peaked at a bud length of 0.75 cm. Treated the HPRL model rats with different buds of malt, the PRL level was decreased, the number of PRLpositive cells and the mRNA expression level in the pituitary were significantly declined, and the number of dopamine D1 and D2 receptors in the hypothalamus was increased. The above changes were most significant in 0.75 cm bud. These results suggest that in terms of the content of effective substance and the effects on HPRL model rats, a malt bud length of 0.75 cm is optimal for clinical application.
Texto completo:
DisponíveL
Índice:
LILACS (Américas)
Assunto principal:
Hordeum
/
Benchmarking
/
Plântula
Limite:
Animais
Idioma:
Inglês
Revista:
Braz. J. Pharm. Sci. (Online)
Assunto da revista:
Farmacologia
/
Teraputica
/
Toxicologia
Ano de publicação:
2021
Tipo de documento:
Artigo
País de afiliação:
China
Instituição/País de afiliação:
College of pharmacy of Xin Jiang Medical University/CN
/
The Third Hospital of Wu-han/CN
/
Wuhan JinYinTan Hospital/CN
Similares
MEDLINE
...
LILACS
LIS