Leukocyte reduction filters as an alternative source of peripheral blood leukocytes for research
Hematol., Transfus. Cell Ther. (Impr.)
;
43(4): 494-498, Oct.-Dec. 2021. ilus
Artigo
em Inglês
| LILACS
| ID: biblio-1350801
ABSTRACT
ABSTRACT Introduction:
Peripheral blood leukocytes are a suitable cell model for science research. However, blood samples from healthy volunteers are limited in volume and difficult to obtain due to the complexity of volunteer recruitment.Objective:
Therefore, it is urgent to find an alternative source of peripheral blood leukocytes.Method:
One of the possibilities is the use of leukocyte reduction filters (LRFs) in blood banks that is used for preparation of leukoreduced blood products. More than 90% of the leukocytes are trapped in the leukofilters allowing the desired blood product to pass through.Results:
It has been reported that the biological function of leukocytes collected from the filters are no different from those isolated from buffy coats, leukapheresis products and whole blood (WB) cells. Moreover, LRFs are waste products that are discarded after leukoreduction.Conclusion:
Thus, leukofilters represent an economic source of human cell populations that can be used for a variety of investigative purposes, with no cost. In the present study, we reviewed the different usage of LRFs in the research, clinical and commercial applications.
Texto completo:
DisponíveL
Índice:
LILACS (Américas)
Assunto principal:
Procedimentos de Redução de Leucócitos
Idioma:
Inglês
Revista:
Hematol., Transfus. Cell Ther. (Impr.)
Assunto da revista:
Hematologia
/
TransfusÆo de Sangue
Ano de publicação:
2021
Tipo de documento:
Artigo
País de afiliação:
Irã
Instituição/País de afiliação:
High Institute for Research and Education in Transfusion Medicine/IR
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