Outcomes associated with Hydroxychloroquine and Ivermectin in hospitalized patients with COVID-19: a single-center experience
Rev. Assoc. Med. Bras. (1992)
;
67(10): 1466-1471, Oct. 2021. tab, graf
Artigo
em Inglês
| LILACS
| ID: biblio-1351431
ABSTRACT
SUMMARY OBJECTIVE:
Hydroxychloroquine and Ivermectin are advocated as potential treatments for coronavirus disease 2019 (COVID-19) despite the lack of supportive clinical evidence. In this study, outcomes associated with Hydroxychloroquine and/or Ivermectin were determined in a series of patients with confirmed COVID-19 from a single institution in Brazil.METHODS:
Consecutive patients admitted between March and July 2020 were retrospectively analyzed and divided into four treatment categories no treatment (Group 0), Ivermectin only (Group I), Hydroxychloroquine only (Group II), and Hydroxychloroquine and Ivermectin (Group III). Intensive care unit admission, mechanical ventilation, and death were compared between the Groups.RESULTS:
A total of 230 patients were included, with the following treatment distribution 35.2% (0), 9.1% (I), 48.3% (II), and 7.4% (III). Groups I, II, and III had the higher rates of Intensive care unit admission, mechanical ventilation, or death (0 23.5% versus I 38.1% versus II 37.8% versus III 70.6%, p=0.002), and the greatest mortality was found in Group III (0 versus III 13.6% versus 35.3%, p=0.03). In the multivariate analysis, Hydroxychloroquine remained significantly associated with death (OR 3.3, 95%CI 1.1-9.6, p=0.03).CONCLUSION:
In a series of consecutive hospitalized patients with COVID-19, Ivermectin was not associated with improved outcomes and Hydroxychloroquine may have resulted in a harmful effect.
Texto completo:
DisponíveL
Índice:
LILACS (Américas)
Assunto principal:
COVID-19
/
Hidroxicloroquina
Tipo de estudo:
Estudo observacional
/
Fatores de risco
Limite:
Humanos
Idioma:
Inglês
Revista:
Rev. Assoc. Med. Bras. (1992)
Ano de publicação:
2021
Tipo de documento:
Artigo
País de afiliação:
Brasil
Instituição/País de afiliação:
Hospital Samaritano/BR
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