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Factors associated with diagnosis of stages I and II lung cancer: a multivariate analysis
Emmerick, Isabel Cristina Martins; Singh, Anupama; Powers, Maggie; Lou, Feiran; Lin, Poliana; Maxfield, Mark; Uy, Karl.
  • Emmerick, Isabel Cristina Martins; University of Massachusetts. Medical School. Department of Surgery. Worcester. US
  • Singh, Anupama; University of Massachusetts. Medical School. Worcester. US
  • Powers, Maggie; University of Massachusetts. Medical School. Department of Surgery. Worcester. US
  • Lou, Feiran; University of Massachusetts. Medical School. Department of Surgery. Worcester. US
  • Lin, Poliana; University of Massachusetts. Medical School. Department of Surgery. Worcester. US
  • Maxfield, Mark; University of Massachusetts. Medical School. Department of Surgery. Worcester. US
  • Uy, Karl; University of Massachusetts. Medical School. Department of Surgery. Worcester. US
Rev. saúde pública (Online) ; 55: 1-10, 2021. tab, graf
Artigo em Inglês | LILACS, BBO | ID: biblio-1352183
ABSTRACT
ABSTRACT OBJECTIVE To present the overall survival rate for lung cancer and identify the factors associated with early diagnosis of stage I and II lung cancer. METHODS This is a retrospective cohort study including individuals diagnosed with lung cancer, from January 2009 to December 2017, according to the cancer registry at UMass Memorial Medical Center. Five-year overall survival and its associated factors were identified by Kaplan-Meier curves and Cox's proportional hazards model. Factors associated with diagnosing clinical stage I and II lung cancer were identified by bivariate and multivariate backward stepwise logistic regression (Log-likelihood ratio (LR)) at 95% confidence interval (CI). RESULTS The study was conducted with data on 2730 individuals aged 67.9 years on average, 51.5% of whom female, 92.3% white, and 6.6% never smoked. Five-year overall survival was 21%. Individuals diagnosed with early-stage disease had a 43% five-year survival rate compared to 8% for those diagnosed at late stages. Stage at diagnosis was the main factor associated with overall survival [HR = 4.08 (95%CI 3.62-4.59)]. Factors associated with early diagnosis included patients older than 68 years [OR = 1.23 (95%CI 1.04-1.45)], of the female gender [OR = 1.47 (95%CI 1.24-1.73)], white [OR = 1.63 (95%CI 1.16-2.30)], and never-smokers [OR = 1.37 (95%CI 1.01-1.86)]; as well as tumors affecting the upper lobe [OR = 1.46 (95%CI 1.24-1.73)]; adenocarcinoma [OR = 1.43 (95%CI 1.21-1.69)]; and diagnosis after 2014 [OR = 1.61 (95%CI 1.37-1.90)]. CONCLUSIONS Stage at diagnosis was the most decisive predictor for survival. Non-white and male individuals were more likely to be diagnosed at a late stage. Thus, promoting lung cancer early diagnosis by improving access to health care is vital to enhance overall survival for individuals with lung cancer.
Assuntos


Texto completo: DisponíveL Índice: LILACS (Américas) Assunto principal: Neoplasias Pulmonares Tipo de estudo: Estudo diagnóstico / Estudo observacional / Estudo prognóstico / Fatores de risco / Estudo de rastreamento Limite: Feminino / Humanos / Masculino País/Região como assunto: América do Sul / Brasil Idioma: Inglês Revista: Rev. saúde pública (Online) Assunto da revista: Sa£de P£blica Ano de publicação: 2021 Tipo de documento: Artigo País de afiliação: Estados Unidos Instituição/País de afiliação: University of Massachusetts/US

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Texto completo: DisponíveL Índice: LILACS (Américas) Assunto principal: Neoplasias Pulmonares Tipo de estudo: Estudo diagnóstico / Estudo observacional / Estudo prognóstico / Fatores de risco / Estudo de rastreamento Limite: Feminino / Humanos / Masculino País/Região como assunto: América do Sul / Brasil Idioma: Inglês Revista: Rev. saúde pública (Online) Assunto da revista: Sa£de P£blica Ano de publicação: 2021 Tipo de documento: Artigo País de afiliação: Estados Unidos Instituição/País de afiliação: University of Massachusetts/US