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Oropharyngeal colostrum immunotherapy and nutrition in preterm newborns: meta-analysis
Xavier Ramos, Michelle de Santana; Martins, Camilla da Cruz; Souza, Elivan Silva; Vieira, Graciete Oliveira; Gomes-Filho, Isaac Suzart; Figueiredo, Ana Claudia Morais Godoy; Pereira, Maurício Gomes; Cruz, Simone Seixas da.
Afiliação
  • Xavier Ramos, Michelle de Santana; Universidade Estadual de Feira de Santana. Departamento de Saúde. Feira de Santana. BR
  • Martins, Camilla da Cruz; Universidade Estadual de Feira de Santana. Departamento de Saúde. Feira de Santana. BR
  • Souza, Elivan Silva; Universidade de Brasília. Faculdade de Ciências da Saúde. Brasília. BR
  • Vieira, Graciete Oliveira; Universidade Estadual de Feira de Santana. Departamento de Saúde. Feira de Santana. BR
  • Gomes-Filho, Isaac Suzart; Universidade Estadual de Feira de Santana. Departamento de Saúde. Feira de Santana. BR
  • Figueiredo, Ana Claudia Morais Godoy; Secretaria de Estado de Saúde do Distrito Federal. Brasilia. BR
  • Pereira, Maurício Gomes; Universidade de Brasília. Escola de Medicina. Brasilia. BR
  • Cruz, Simone Seixas da; Universidade Estadual de Feira de Santana. Departamento de Saúde. Feira de Santana. BR
Rev. saúde pública (Online) ; 55: 1-11, 2021. tab, graf
Article em En | LILACS, BBO | ID: biblio-1352195
Biblioteca responsável: BR1.1
ABSTRACT
ABSTRACT OBJECTIVE To investigated the effect of oropharyngeal colostrum immunotherapy in reducing the time required for very low birth weight preterm newborns (VLBW-PTNB < 1,500g and < 37 weeks) to achieve full enteral nutrition. METHODS Literature search was conducted using four databases, including gray literature, with additional manual search of the references of selected articles. Eligibility criteria consisted of randomized clinical trials, without restriction regarding the date or language of the publication. Two independent reviewers performed the article selection and data extraction. The random-effects meta-analysis used a non-standard technique to assess the mean difference in days to achieve full enteral nutrition, carried out by the Stata 15 statistic program. RESULTS The systematic review comprised 10 studies, and five were selected for meta-analysis, with a population of 764 VLBW-PTNB and gestational age of birth between 25 and 32 weeks. The studies were conducted between 2011 and 2018 in North America, Asia and Africa, with only one conducted in South America. Altogether, they reported the number of days it took 708 VLBW-PTNB to achieve full enteral nutrition, with newborns treated with immunotherapy showing a shorter time in only three studies. Meta-analysis showed a mean difference of -4.26 days, (95% CI -7.44; -1.08d), with high heterogeneity (I2 = 83.1%). CONCLUSION The use of oropharyngeal colostrum immunotherapy can reduce the time for VLBW-PTNB to achieve full nutrition when compared to those who used a placebo or received routine care.
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Texto completo: 1 Índice: LILACS Assunto principal: Colostro / Enterocolite Necrosante Tipo de estudo: Clinical_trials / Guideline / Systematic_reviews Limite: Child, preschool / Female / Humans / Infant / Pregnancy País/Região como assunto: America do sul / Brasil Idioma: En Revista: Rev. saúde pública (Online) Assunto da revista: Sa£de P£blica Ano de publicação: 2021 Tipo de documento: Article

Texto completo: 1 Índice: LILACS Assunto principal: Colostro / Enterocolite Necrosante Tipo de estudo: Clinical_trials / Guideline / Systematic_reviews Limite: Child, preschool / Female / Humans / Infant / Pregnancy País/Região como assunto: America do sul / Brasil Idioma: En Revista: Rev. saúde pública (Online) Assunto da revista: Sa£de P£blica Ano de publicação: 2021 Tipo de documento: Article