Fecal calprotectin levels used as a noninvasive method for screening for chronic gastritis in pediatric patients. A descriptive study
São Paulo med. j
;
139(6): 564-569, Nov.-Dec. 2021. tab, graf
Artigo
em Inglês
| LILACS
| ID: biblio-1352283
ABSTRACT
ABSTRACT BACKGROUND:
Gastritis consists of inflammation of the gastric mucosa and is one of the main causes of dyspeptic symptoms in children.OBJECTIVE:
To investigate the presence of inflammation by evaluating fecal calprotectin (FC) in children diagnosed with chronic gastritis. DESIGN ANDSETTING:
Descriptive study in Pediatric Gastroenterology Department of Ondokuz Mayis University Hospital in Turkey.METHODS:
Between January 2016 and July 2018, FC levels were compared retrospectively in children with chronic gastritis (histopathology-based diagnosis), patients with inflammatory bowel disease (IBD) and healthy children.RESULTS:
A total of 67 chronic gastritis patients (61.2% girls) with a mean age of 13.09 ± 3.5 years were evaluated. The mean FC levels were 153.4 μg/g in the chronic gastritis group, 589.7 μg/g in the IBD group and 43.8 μg/g in the healthy group. These levels were higher in chronic gastritis patients than in healthy individuals (P = 0.001) and higher in IBD patients than in the other two groups (P < 0.001). The FC level in the patients with chronic active gastritis (156.3 μg/g) was higher than in those with chronic inactive gastritis (150.95 μg/g) (P = 0.011). Among the patients with chronic active gastritis, the FC level was significantly higher in Helicobacter pylori-positive individuals than in negative individuals (P = 0.031).CONCLUSION:
We confirmed the association between increased FC and chronic gastritis. Elevated FC levels may be seen in patients with chronic active gastritis. In order to be able to use FC as a screening tool for chronic gastritis, further studies in a larger study group are needed.
Texto completo:
DisponíveL
Índice:
LILACS (Américas)
Assunto principal:
Doenças Inflamatórias Intestinais
/
Gastrite
Tipo de estudo:
Estudo diagnóstico
/
Estudo observacional
/
Fatores de risco
/
Estudo de rastreamento
Limite:
Adolescente
/
Criança
/
Feminino
/
Humanos
/
Masculino
Idioma:
Inglês
Revista:
São Paulo med. j
Assunto da revista:
Cirurgia Geral
/
Cincia
/
Ginecologia
/
Medicina
/
Medicina Interna
/
Obstetr¡cia
/
Pediatria
/
Sa£de Mental
/
Sa£de P£blica
Ano de publicação:
2021
Tipo de documento:
Artigo
País de afiliação:
Turquia
Instituição/País de afiliação:
University Faculty of Medicine/TR
Similares
MEDLINE
...
LILACS
LIS