Morphological characteristics, classifications and difficulties in the use of diagnostic criteria for serrated lesions of the large intestine
J. coloproctol. (Rio J., Impr.)
;
41(4): 430-437, Out.-Dec. 2021. tab, ilus
Artigo
em Inglês
| LILACS
| ID: biblio-1356440
ABSTRACT
Abstract Introduction Colorectal carcinoma (CRC) is the most common gastrointestinal neoplasm in the world, accounting for 15% of cancer-related deaths. This condition is related to different molecular pathways, among them the recently described serrated pathway, whose characteristic entities, serrated lesions, have undergone important changes in their names and diagnostic criteria in the past thirty years. The multiplicity of denominations and criteria over the last years may be responsible for the low interobserver concordance (IOC) described in the literature. Objectives:
The present study aims to describe the evolution in classification of serrated lesions, based on the last three publications of theWorld Health Organization (WHO) and the reproducibility of these criteria by pathologists, based on the evaluation of the IOC.Methods:
A search was conducted in the PubMed, ResearchGate and Portal Capes databases, with the following terms sessile serrated lesion; serrated lesions; serrated adenoma; interobserver concordance; andreproducibility.Articlespublished since 1990were researched. Results andDiscussion:
The classification of serrated lesions in the past thirty years showed different denominations and diagnostic criteria. The reproducibility and IOC of these criteria in the literature, based on the kappa coefficient, varied in most studies, from very poor to moderate.Conclusions:
Interobserver concordance and the reproducibility of microscopic criteria may represent a limitation for the diagnosis andappropriatemanagementof these lesions. It is necessary to investigate diagnostic tools to improve the performance of the pathologist's evaluation, for better concordance, and, consequently, adequate diagnosis and treatment. (AU)
Texto completo:
DisponíveL
Índice:
LILACS (Américas)
Assunto principal:
Ferimentos e Lesões
/
Intestino Grosso
Tipo de estudo:
Estudo diagnóstico
/
Revisões Sistemáticas Avaliadas
Limite:
Humanos
Idioma:
Inglês
Revista:
J. coloproctol. (Rio J., Impr.)
Assunto da revista:
Cirurgia
/
Doenas Retais
/
Doenas do Colo
/
Gastroenterologia
/
Cirurgia
Ano de publicação:
2021
Tipo de documento:
Artigo
País de afiliação:
Brasil
Instituição/País de afiliação:
Universidade Federal do Rio de Janeiro/BR
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