Overview of polymyxin resistance in Enterobacteriaceae
Rev. Soc. Bras. Med. Trop
;
55: e0349, 2022. graf
Artigo
em Inglês
|
LILACS-Express
| LILACS
| ID: biblio-1360814
ABSTRACT
ABSTRACT Polymyxin antibiotics are disfavored owing to their potential clinical toxicity, especially nephrotoxicity. However, the dry antibiotic development pipeline, together with the increasing global prevalence of infections caused by multidrug-resistant (MDR) gram-negative bacteria, have renewed clinical interest in these polypeptide antibiotics. This review highlights the current information regarding the mechanisms of resistance to polymyxins and their molecular epidemiology. Knowledge of the resistance mechanisms and epidemiology of these pathogens is critical for the development of novel antibacterial agents and rapid treatment choices.
Texto completo:
DisponíveL
Índice:
LILACS (Américas)
Tipo de estudo:
Fatores de risco
Idioma:
Inglês
Revista:
Rev. Soc. Bras. Med. Trop
Assunto da revista:
Medicina Tropical
Ano de publicação:
2022
Tipo de documento:
Artigo
/
Documento de projeto
País de afiliação:
Brasil
Instituição/País de afiliação:
Universidade Federal da Grande Dourados/BR
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