Absence of an association between serum interleukin-6 and brain-derived neurotrophic factor in drug-naïve first-episode major depression
Arch. Clin. Psychiatry (Impr.)
;
48(5): 229-230, Sept.-Oct. 2021. tab, graf
Artigo
em Inglês
|
LILACS-Express
| LILACS
| ID: biblio-1364287
ABSTRACT
ABSTRACT Peripheral and central cytokine interleukin-6 (IL-6) levels play an important role in the pathophysiology of major depression (MD). We investigated the association between serum levels of IL-6 and brain-derived neurotrophic factor (BDNF) in drug-naïve, first-episode patients with MD. This study included 28 patients (male/female 11/17; mean [standard deviation] age, 46.7 [11.9] years) who met the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition criteria for MD without any physical diseases. We evaluated the severity of depression using the Hamilton Rating Scale for Depression. No associations were found between serum levels of IL-6 and BDNF (r=-0.102, P =0.605). These results suggest that IL-6 does not influence BDNF and vice versa, but both act in a peripheral manner.
Texto completo:
DisponíveL
Índice:
LILACS (Américas)
Tipo de estudo:
Guia de Prática Clínica
/
Estudo prognóstico
/
Fatores de risco
Idioma:
Inglês
Revista:
Arch. Clin. Psychiatry (Impr.)
Assunto da revista:
Psiquiatria
Ano de publicação:
2021
Tipo de documento:
Artigo
País de afiliação:
Japão
Instituição/País de afiliação:
University of Occupational and Environmental Health/JP
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