Persistent SARS-CoV-2 antigen presence in multiple organs of a naturally infected cat from Brazil
J. venom. anim. toxins incl. trop. dis
;
28: e20210074, 2022. ilus
Artigo
em Inglês
| LILACS, VETINDEX
| ID: biblio-1365077
ABSTRACT
Background:
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the etiological agent of the disease coronavirus 2019 (COVID-19) in humans. SARS-CoV-2 has been identified in cats with or without clinical signs. Case presentation We describe the pathological and molecular findings in a six-month-old asymptomatic cat with SARS-CoV-2 infection from Brazil, belonging to a human family with COVID-19 cases. The pool of nasopharynx and oropharynx swabs at day zero tested positive by RT-qPCR for SARS-CoV-2. No amplification resulted from molecular testing performed on days 7 and 14. The cat was hit by a car and died 43 days after the molecular diagnosis. Immunohistochemistry at post-mortem examination demonstrated nucleocapsid protein in samples from the lungs, kidneys, nasal conchae, trachea, intestine, brain and spleen.Conclusion:
The present study has highlighted the possibility that viral antigens can be detected by immunohistochemistry in multiple organs six weeks after infection, although the same tissues tested negative by RT-PCR.(AU)
Texto completo:
DisponíveL
Índice:
LILACS (Américas)
Assunto principal:
Imuno-Histoquímica
/
SARS-CoV-2
/
COVID-19
/
Antígenos
Tipo de estudo:
Estudo prognóstico
Limite:
Animais
País/Região como assunto:
América do Sul
/
Brasil
Idioma:
Inglês
Revista:
J. venom. anim. toxins incl. trop. dis
Assunto da revista:
Toxicologia
Ano de publicação:
2022
Tipo de documento:
Artigo
País de afiliação:
Brasil
/
Estados Unidos
Instituição/País de afiliação:
Federal Rural University of Rio de Janeiro/BR
/
Federal University of Mato Grosso/BR
/
Federal University of Paraná/BR
/
Oregon State University/US
/
Purdue University/US
/
University of Washington/US
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